Fundamental and clinical assessment of F-18 Choline as a new cancer tracer for PET

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592398
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Iwate Medical University
• Principal Investigator: SHOZUSHIMA Masanori 岩手医科大学, 歯学部, 教授 (00118259)
• Co-Investigator(Kenkyū-buntansha): TERASAKI Kazunori 岩手医科大学, 医学部, 講師 (60285632)
• Project Period (FY): 2009 – 2011
• Keywords: PET / 18F-コリン / FDG-PET

Research Abstract

This study evaluated the potential usefulness of[^<18> F] Choline as a new cancer tracer for PET. The uptake of[^<18> F] Choline and[^<18> F] FDG are cell cycle dependent, are associated with the proliferative activity of the tumor seen during PET imaging. The average SUVs of[^<18> F] FDG for the gingival cancer infiltrated jawbone was markedly higher than that for the tongue. The average SUVs of[^<11> C] or[^<18> F] Choline were showing no significant difference between the tongue and gingival cancer, and the same level as[^<18> F] FDG uptake for the tongue cancer. It seems that[^<18> F] Choline is not well incorporated to the osteogenetic cell and the osteoclast related to bone metabolism but accumulation for the cancer cells.

Research Products

• [Journal Article] Preoperative central benzodiazepine receptor binding potential and cerebral blood flow images on SPECT predict development of new cerebral ischemic events and cerebral hyperperfusion after carotid endarterectomy (2011)
  • Author(s): Sato Y., Ogasawara K., Kuroda H., Suzuki T., Chida K., Fujiwara S., Aso K., Kobayashi M., Yoshida K., Terasaki K., Ogawa A.
  • Journal Title: Journal of Nuclear Medicine Volume: 52 Pages: 1400-1407
  • Peer Reviewed
• [Journal Article] Central benzodiazepine receptor binding potential and CBF images on SPECT correlate with oxygen extraction fraction images on PET in the cerebral cortex with unilateral major cerebral artery occlusive disease (2011)
  • Author(s): Chida K., Ogasawara K., Kuroda H., Aso K., Kobayashi M., Fujiwara S., Yoshida K., Terasaki K., Ogawa A.
  • Journal Title: Journal of Nuclear Medicine Volume: 52 Pages: 511-518
  • Peer Reviewed
• [Journal Article] A characteristic of FDG-PET for the gingival cancer (2010)
  • Author(s): Shozushima M., Hara Y., Terasaki K., Goto S., Iwata R.
  • Journal Title: NMCC Annual Report Volume: 16 Pages: 24-28
• [Journal Article] Postcarotid endarterectomy improvement in cognition is associated with resolution of crossed cerebellar hypoperfusion and increase in^<123> I-iomazenil uptake in the cerebral cortex : a SPECT study (2010)
  • Author(s): Chida K., Ogasawara K., Aso K., Suga Y., Kobayashi M., Yoshida K., Terasaki K., Tsushina E., Ogawa A.
  • Journal Title: Cerebrovascular Diseases Volume: 29 Pages: 343-351
  • Peer Reviewed
• [Journal Article] 舌下腺に原発し超音波パワードプラ法が診断に有効であった悪性リンパ腫の一例 (2009)
  • Author(s): 東海林理、熊谷章子、杉山芳樹、武田泰典、小豆島正典
  • Journal Title: 岩手医科大学歯学雑誌 Volume: 34 Pages: 22-28
  • Peer Reviewed
• [Journal Article] Cell cycle dependency of^<18> F-Choline and^<18> FDG uptake during proliferation of cultured human cancer cells (2009)
  • Author(s): Shozushima M., Yamamoto J., Hara Y., Terasaki K., Goto S., Iwata R.
  • Journal Title: NMCC Annual Report Volume: 15 Pages: 231-234
• [Journal Article] Brain temperature measured using proton MR spectroscopy detects cerebral hemodynamic impairment in patients with unilateral chronic major cerebral artery steno-occlusive disease : comparison with positron emission tomography (2009)
  • Author(s): Ishigaki D., Ogasawara K., Yoshioka Y., Chida K., Sasaki M., Fujiwara S., Aso K., Kobayashi M., Yoshida K., Terasaki K., Inoue T., Ogawa A.
  • Journal Title: Stroke Volume: 40 Pages: 3012-3016
  • Peer Reviewed
• [Presentation] Consistency of imaging and pathological diagnosis using CBCT in head and neck disease (2011)
  • Author(s): Saitoh K, Shoji S, Izumisawa M, Takahashi N, Saitoh K, Shozushima M
  • Organizer: 18th International Congress of Dento Maxillo Facial Radiology
  • Place of Presentation: Hiroshima
  • Year and Date: 2011-05-29
• [Presentation] 特別講演:口腔癌に対するFDG集積の特徴 (2011)
  • Author(s): 小豆島正典
  • Organizer: 18th International Congress of Dento Maxillo Facial Radiology
  • Place of Presentation: Hiroshima
  • Year and Date: 2011-05-29
• [Presentation] A characteristic of FDG-PET for the gingival cancer infiltrated to bone (2010)
  • Author(s): Shozushima M., Hara Y., Terasaki K., Sugiyama Y.
  • Organizer: The 8th Asian Congress of Oral and Maxillo Facial Radiolog
  • Place of Presentation: Soul
  • Year and Date: 20101100
• [Presentation] ^<18> F-Cholineによる口腔癌の診断 (2010)
  • Author(s): 原康文, 寺崎一典、岩田錬、小豆島正典、杉山芳樹
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: さいたま市
  • Year and Date: 2010-11-11
• [Presentation] 下顎骨に発生した良性骨芽細胞腫の一例 (2010)
  • Author(s): 齋藤圭輔、泉澤充、東海林理、高橋徳明、佐藤仁、星野正行、古城慎太郎、水城春美、小豆島正典
  • Organizer: 日本歯科放射線学会、臨床画像大会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2010-09-05
• [Presentation] 口腔癌に対するFDGと^<18> F-choline集積の比較 (2010)
  • Author(s): 小豆島正典
  • Organizer: 第16回NMCC共同利用研究成果発表会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-14
• [Presentation] ループ標識法を用いた[^<11> C] PK11195の迅速・効率的な合成法の検討 (2009)
  • Author(s): 寺崎一典、石川洋一、小豆島正典、世良耕一郎、岩田錬
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川市
  • Year and Date: 2009-10-01
• [Presentation] Cell cycle dependency of^<18> F-Choline uptake during proliferation of cultured human cancer cells (2009)
  • Author(s): Shozushima M., Terasaki K., Hara Y., Yamamoto J.
  • Organizer: 17th International Congress of Dento maxilla facial Radiology
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2009-06-28
• [Presentation] [^<11> C] PK11195の迅速・効率的な合成法の開発 (2009)
  • Author(s): 寺崎一典、石川洋一、岩田錬、後藤祥子、小豆島正典
  • Organizer: 第15回NMCC共同利用研究成果発表会
  • Place of Presentation: 盛岡市
  • Year and Date: 2009-05-16
• [Presentation] FDGと^<18> F-Choline集積の細胞周期依存性の比較 (2009)
  • Author(s): 小豆島正典、山本純子、寺崎一典、後藤祥子
  • Organizer: 第15回NMCC共同利用研究成果発表会
  • Place of Presentation: 盛岡市
  • Year and Date: 2009-05-16
• [Presentation] 頭頸部癌に対する^<18> F-choline PETの使用経験 (2009)
  • Author(s): 原康文、古屋出、宮形養、西平宗功、星秀樹、杉山芳樹、寺崎一典、小豆島正典
  • Organizer: 第15回NMCC共同利用研究成果発表会
  • Place of Presentation: 盛岡市
  • Year and Date: 2009-05-16
• [Book] 「Q & A」で学ぶ歯科放射線学: SBOs (2011)
  • Author(s): 金田隆・小豆島正典, ほか10名
  • Publisher: 学建書院