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2011 Fiscal Year Final Research Report

Intraoral pH measurement of different carious lesions with qPCR of cariogenic bacteria to differentiate caries activity

Research Project

  • PDF
Project/Area Number 21592413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KITASAKO Yuichi  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (30361702)

Co-Investigator(Kenkyū-buntansha) TAGAMI Jyunji  東京医科歯科大学, 医歯学総合研究科, 教授 (50171567)
Co-Investigator(Renkei-kenkyūsha) MATIN Khairul  東京医科歯科大学, 医歯学総合研究科, 特任講師 (00372433)
Project Period (FY) 2009 – 2011
Keywords象牙質う蝕 / う蝕活動性 / う蝕部位 / う蝕診断 / pH / う蝕原因細菌 / 遺伝子分析
Research Abstract

This study was aimed to measure pH of 103 dentin carious lesions intraorally using a micro-pH sensor, and assess predominant acid-producing cariogenic bacteria in each lesion by real-time PCR to differentiate caries activities. 50 samples were diagnosed as active and 53 as arrested lesions. Statistically significant difference was observed on average surface pH value of approximal and cervical lesions between active and arrested lesions. Prevalence of Lactobacillus spp. was higher in active approximal and cervical lesions than in occlusal and root lesions.

  • Research Products

    (19 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Gum Containing CalciumFluoride Reinforces Enamel SubsurfaceLesions in situ2012

    • Author(s)
      Kitasako Y, Sadr A, Hamba H, Ikeda M, Tagami J
    • Journal Title

      Journal of DentalResearch

      Volume: 91 Pages: 370-375

    • Peer Reviewed
  • [Journal Article] Intraoral pHmeasurement of carious lesions withqPCR of cariogenic bacyeria todifferentiate caries activity2012

    • Author(s)
      Kuribayashi M, Kitasako Y, Matin K, Sadr A, Shida K, Tagami J
    • Journal Title

      Journal of Dentistry

      Volume: 40 Pages: 222-228

    • Peer Reviewed
  • [Journal Article] Effect of a chewinggum containing phosphoryloligosaccharides of calcium(POs-Ca) and fluoride on remineralization andcrystallization of enamel subsurfacelesions in situ2011

    • Author(s)
      Kitasako Y, Tanaka M, Sadr A, Hamba H, Ikeda M, Tagami J
    • Journal Title

      Journal of Dentistry

      Volume: 39 Pages: 771-779

    • Peer Reviewed
  • [Journal Article] Relationship between perception ofdifficulty and clinical experience ofapproximal composite restorations infinal-year undergraduate students atTokyo Medical and Dental University2011

    • Author(s)
      Kitasako Y, Sadr A, Nikaido T, Tagami J
    • Journal Title

      Journal of Medical and Dental Sciences

      Volume: 58 Pages: 1-5

    • Peer Reviewed
  • [Journal Article] Ten-year observation of dentin bondingdurability of 4-META/MMA-TBB resincement-a SEM and TEM study2011

    • Author(s)
      Aoki K, Kitasako Y, Ichinose S, Burrow MF, Ariyoshi M, Nikaido T, Tagami J
    • Journal Title

      Dental Material Journal

      Volume: 30 Pages: 438-447

  • [Journal Article] Roghness and pH changes of enamelsurface induced by soft drinks invitro-applications of stylus profilometry2011

    • Author(s)
      Fujii M, Kitasako Y, Sadr A, Tagami J
    • Journal Title

      focus variation 3D scanning microscopyand micro pH sensor. Dental Material Journal

      Volume: 30 Pages: 404-410

  • [Journal Article] An artificial biofilm inducedsecondary caries model for in vitrostudies2011

    • Author(s)
      Hayati F, Okada A, Kitasako Y Tagami J, Matin K
    • Journal Title

      Australian Dental Journal

      Volume: 58 Pages: 40-47

  • [Journal Article] The clinicalapplication of surface pH measurementsto longitudinally assess white spotenamel lesions2010

    • Author(s)
      Kitasako Y, Cochrane NJ, Matin K, Shida K, Adams GG, Burrow MF, Reynolds EC, Tagami J
    • Journal Title

      Journal of Dentistry

      Volume: 38 Pages: 584-590

  • [Journal Article] Foxton RM, Tagami J. Effectof dentin pretreatment with mild acidicHOCl solution on microtensile bondstrength and surface pH2010

    • Author(s)
      Kunawarote S, Nakajima M, Shida K, Kitasako Y
    • Journal Title

      Journal of Dentistry

      Volume: 38 Pages: 261-268

  • [Journal Article] 各種飲食物の酸性度と酸蝕歯の関係2010

    • Author(s)
      北迫勇一
    • Journal Title

      日本歯科医師会雑誌

      Volume: 63 Pages: 19-27

  • [Journal Article] simplified quantitative test-adaptedCheckbuf test-for resting saliva bufferingcapacity compared with a standard test2009

    • Author(s)
      Kitasako Y, Burrow MF, Huq LN, Stacey MA, Reynolds EC, Tagami J. A
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 108 Pages: 551-556

    • Peer Reviewed
  • [Presentation] エナメル質初期う蝕最表層部におけるPOs-Caおよびフッ素配合ガム咀嚼後の微小硬さ変化ならびにフッ素分布2011

    • Author(s)
      北迫勇一、池田正臣、小林隆嗣、田中智子、釜阪寛、Alireza Sadr、田上順次
    • Organizer
      日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
  • [Presentation] 保存修復学実習で使用する歯科用バーの選択に関する学生の理解度2011

    • Author(s)
      北迫勇一、池田正臣、田上順次
    • Organizer
      日本歯科医学教育学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-16
  • [Presentation] 唾液分泌量および唾液緩衝能と最大咬合圧の関連性2011

    • Author(s)
      田中美由紀、北迫勇一、池田正臣、田上順次
    • Organizer
      日本歯科保存学会春季学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-06-10
  • [Presentation] Evaluation of low erosive drinkwith phosphoryl oligosaccharides of calcium2011

    • Author(s)
      Mita H, Kitasako Y, Takagaki T, Tagami J
    • Organizer
      89th IADR General Session
    • Place of Presentation
      USA
    • Year and Date
      2011-03-18
  • [Presentation] 各種う蝕部位におけるう蝕除去前後のpH変化とう蝕最近叢qPCR解析2010

    • Author(s)
      栗林恵美、北迫勇一、マティンカイルール、田上順次
    • Organizer
      日本歯科保存学会秋季学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-28
  • [Presentation] POs-Caおよびフッ素配合ガム咀嚼後のエナメル質初期う蝕の再石灰化効果および微小硬さ変化2010

    • Author(s)
      北迫勇一、半場秀典、Alireza Sadr、二階堂徹、池田正臣、田中智子、滝井寛、釜阪寛、田上順次
    • Organizer
      日本歯科保存学会秋季学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-28
  • [Presentation] Dentin bonddurability of 4-META/MMA-TBB resincement after ten years2010

    • Author(s)
      Aoki K, Kitasako Y, Burrow MF, Ariyoshi M, Nikaido T, Tagami J
    • Organizer
      88th IADR General Session
    • Place of Presentation
      Spain
    • Year and Date
      2010-06-14
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/ope/ope-J.htm

URL: 

Published: 2013-07-31  

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