2011 Fiscal Year Final Research Report
Development of the cell-responsive DDS carrier suitable for bone formation and anti-cancer effects
Project/Area Number |
21592489
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HAMADA Junichi 北海道大学, 遺伝子病制御研究所, 准教授 (50192703)
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Project Period (FY) |
2009 – 2011
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Keywords | 顎骨再生 / DDS担体 / 歯学 |
Research Abstract |
The objective of this study was to develop chitosan/hydroxyapatite(HAp) composite suitable for jaw regeneration, develop DDS technology for growth factors, and estimate bone formation and anti-cancer effects of the composites. By using the co-precipitation and porogen-leaching method, we developed a novel chitosan/HAp composite with various porosities, which was found to be mechanically flexible and easily formed into any desired shape. The composites with rhBMP-2 resulted in active bone formation. These results suggested that the composite was an effective material as a DDS carrier. Misexpressions of PRL-3 genes are implicated in the development of oral SCC. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. We plan to develop DDS materials which will act in the response with HOX genes expressions.
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[Journal Article] PAX4 has the potential to function as a tumor suppressor in human melanoma2008
Author(s)
Hata, S., Hamada, J., Maeda, K., Murai, T., Tada, M., Furukawa, H., Tsutsumida, A., Saito, A., Yamamoto Y. and Moriuchi, T
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Journal Title
Int. J. Oncol
Volume: 33
Pages: 1065-1071
Peer Reviewed
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