2011 Fiscal Year Final Research Report
The investication of factors related to odontoblast diffenetiation and morphology preservation, and analysis of expression
| Project/Area Number |
21592491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Kazuto 東京大学, 医学部・附属病院, 特任准教授 (30344451)
IINO Mitsuyoshi 山形大学, 医学部・附属病院, 教授 (50212717)
CHIKAZU Daichi 東京医科大学, 医学部・附属病院, 教授 (30343122)
FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKATO Tsuyoshi 東京大学, 医学部・附属病院, 教授 (90171454)
MASUTANI Mitsuko 国立がん研究センター研究所, ゲノム安定性研究分野, 分野長 (60238904)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生歯学 / ポリADP-リボシル化反応 |
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| Research Abstract |
In this report, Parp-1 was suggested to involve in odontoblast/osteoblast differentiation from mesenchymal stem cell(MSC) and factors related to morphology preservation. Through the time course analysis of mice teeth, dysplasia and malformation inside the teeth were found based on the two factors. Parp-1 deficiency and aging. In vitro differentiation inducement from MSCs, odontoblast and osteoblast differentiation was not observed under the inhibition of Parp activity.
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Research Products
(15 results)
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[Journal Article] Improvement in wound healing by a novel synthetic collagen-gel dressing in genetically diabetic mice2010
Author(s)
Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y, Seto I, Iino M, Takato T
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Journal Title
Asian J Oral Maxillofac Surg
Volume: 22(2)
Pages: 61-67
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[Journal Article] Poly(ADP-ribose) glycohydrolase deficiency sensitizes mouse ES cells to particular types of DNA damaging agents2009
Author(s)
Fujihara H, Ogino H, Maeda D, Shirai H, Nozaki T, Kamada N, Jishage K, Tanuma S, Takato T, Nakagama H, Sugimura T, Masutani M
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Journal Title
Curr Cancer Drug Target
Volume: 9(8)
Pages: 953-962
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