2011 Fiscal Year Final Research Report
Immunological approaches to the mechanisms of bisphosphonate-related osteonecrosis of the jaw
| Project/Area Number |
21592511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
DEYAMA Yoshiaki 北海道大学, 大学院・歯学研究科, 准教授 (80271667)
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| Co-Investigator(Kenkyū-buntansha) |
TOTSUKA Yasunori 北海道大学, 大学院・歯学研究科, 教授 (00109456)
YASUDA Motoaki 北海道大学, 大学院・歯学研究科, 准教授 (90239765)
IIZUKA Tadashi 北海道大学, 大学院・歯学研究科, 准教授 (80168062)
YOSHIMURA Yoshitaka 北海道大学, 大学院・歯学研究科, 助教 (30230816)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ビスホスホネート / 顎骨壊死 / 免疫 |
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| Research Abstract |
In this study, we investigated the effects of bisphosphonate on osteoclasts and their precursor cells to clarify one of the mechanisms of bisphosphonate-related osteonecrosis of the jaw(BRONJ). BRONJ-related bisphosphonates strongly inhibited osteoclastogenesis and bone resorption activity. On the other hand, they showed cytotoxicity and enhanced microbial pathogens-induced cell death.
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[Journal Article] Koshiro K, Sano H, Suzuki K, Inoue N, Platinum nanoparticles suppress osteoclastogenesis through scavenging of reactive oxygen species produced in RAW264. 7 cells.2011
Author(s)
Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N
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Journal Title
J Pharmacol Sci.
Volume: 117
Pages: 243-252
DOI
Peer Reviewed
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