2011 Fiscal Year Final Research Report
Testing the utility of rationally engineered recombinant collagen-like proteins for applications of bone regeneration with bone morphogenetic protein in tissue engineering.
| Project/Area Number |
21592520
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ITOH Kenji 名古屋大学, 医学部附属病院, 助教 (50402623)
KINOSHITA Kazuhiko 名古屋大学, 医学部附属病院, 医員 (40467296)
UEDA Minoru 名古屋大学, 大学院・医学系研究科, 教授 (00151803)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | リコンビナント / cDNAカセット / コラーゲン / 骨形成蛋白(BMP) |
|---|
| Research Abstract |
We mapped the D4 domain of human collagen I as most critical for binding site of bone morphogenetic protein(BMP) and used this information to genetically engineer a collagen-like protein consisting of tandem repeats of the D4 domain(mD4 collagen). We proved recombinant human mD4 collagen-like protein had a potential for an efficient scaffold as same as other scaffolds materials for engineering of bone when combined with BMP.
|
Research Products
(6 results)
