2011 Fiscal Year Final Research Report
The elucidation of molecule morbidity of Aurora kinase in oral squamous cell carcinoma, and the application to the medical treatment strategy
| Project/Area Number |
21592552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University (2010-2011)
Shimane University (2009) |
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Principal Investigator |
KONDO Seiji 昭和大学, 歯学部, 准教授 (10432634)
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| Co-Investigator(Kenkyū-buntansha) |
URANO Takeshi 島根大学, 医学部, 教授 (70293701)
SEKINE Joji 島根大学, 医学部, 教授 (20236095)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分裂期キナーゼ |
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| Research Abstract |
It aimed at the elucidation of a molecule background(an expression pattern, an activation mechanism) and pathological significance under considering the medical treatment strategy which made Aurora the target. Establishment of stable expression of each Aurora protein that fused GFP in squamous cell carcinoma cell line was tried, and it succeeded in visualizing the intracellular dynamic state of each Aurora in real time by using of a confocal laser scanning microscope. A possibility that Aurora was an effective molecule target was shown.
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[Journal Article] Evaluation of the anticancer activities of Na+/K+-ATPase inhibitor, sanguinarine in human oral squamous cell carcinoma cell lines2011
Author(s)
H. Tsukamoto, S. Kondo, Y. Mukudai, T. Nagumo, A. Yasuda, Y. Kurihara, H. Watanabe, T. Kamatani, A. Fujita, H. Katsuta, Y. Yoshihama, T. Shirota. S. Shintani
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Journal Title
Anticancer research
Volume: 31
Pages: 2841-2846
Peer Reviewed
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