• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Analysis of cell motility system with EMT in tumor invasion and metastasis of oral cancer

Research Project

  • PDF
Project/Area Number 21592554
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

SHIMASUE Hiroshi  広島大学, 病院, 助教 (40335683)

Co-Investigator(Kenkyū-buntansha) KAMATA Nobuyuki  広島大学, 大学院・医歯薬学総合研究科, 教授 (70242211)
HIGASHIKAWA Koichiro  広島大学, 病院, 講師 (80363084)
Co-Investigator(Renkei-kenkyūsha) SHIGEISHI Hideo  広島大学, 大学院・医歯薬学総合研究科, 助教 (90397943)
Project Period (FY) 2009 – 2011
Keywords口腔癌 / 上皮間葉移行 / 癌の浸潤・転移 / 細胞運動能制御 / Rho
Research Abstract

Snail, a transcription factor and EMT inducer, enable squamous cell carcinoma(SCC) cells to acquire high-invasiveness. Cyr61 is a humoral factor which known to be a angiogenesis factor and a target of which its transcription increases by Snail. Forced expression of Cyr61 in SCC cells directed their high-invasiveness and stimulation of recombinant Cyr61 gained their motility through activation of Rho. These data indicates that both of autocrine and paracrine Cyr61 offers crucial roles for the establishment of local invasion of SCC.

  • Research Products

    (6 results)

All 2011 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] PGE(2) targets squamous cell carcinomacell with the activated epidermal growthfactor receptor family for survival against5-fluorouracil through NR4A2 induction2011

    • Author(s)
      Shigeishi H, Higashikawa K, Hatano H, Okui G, Tanaka F, Tran TT, Rizqiawan A, Ono S, Tobiume K, Kamata N
    • Journal Title

      CancerLett

      Volume: 307(2) Pages: 227-36

    • Peer Reviewed
  • [Journal Article] Lymphangiogenesis andmetastasis : Role of tumor-inducedlymphatic vessel activation inextramammary Paget' s disease2009

    • Author(s)
      Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
    • Journal Title

      Am JPathol

      Volume: 175(5) Pages: 2235-48

    • Peer Reviewed
  • [Journal Article] Overexpression of the receptorfor hyaluronan-mediated motility, correlates with expression ofmicrotubule-associated protein in humanoral squamous cell carcinomas2009

    • Author(s)
      Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, Higashikawa K, Kamata N
    • Journal Title

      Int J Oncol

      Volume: 34(6) Pages: 1565-1571

    • Peer Reviewed
  • [Journal Article] DeltaNp63alpha-dependent expression ofId-3 distinctively suppresses theinvasiveness of human squamous cellcarcinoma2009

    • Author(s)
      Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N
    • Journal Title

      Int J Cancer

      Volume: 124(12) Pages: 2837-2844

    • Peer Reviewed
  • [Presentation] 口腔癌の浸潤能診断(シンポジウム「癌細胞の浸潤・転移」2011

    • Author(s)
      東川晃一郎
    • Organizer
      第65回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-04-21
  • [Presentation] Snailによる転写調節とEMTの誘導(シンポジウム「Epithelial MesennchymalTransitionと腫瘍の転移・浸潤」2009

    • Author(s)
      鎌田伸之, 東川晃一郎(講演者), 飛梅圭
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-03

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi