2011 Fiscal Year Final Research Report
Antitumor effect of neutrophil-derived TRAIL for oral squamous cell carcinoma
| Project/Area Number |
21592562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University (2011)
Showa University (2009-2010) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | TRAIL / 好中球 / アポトーシス / 抗腫瘍効果 |
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| Research Abstract |
BCG and OK432 enhanced TRAIL production and chemotaxis of neutrophils in a dose-dependent manner. Although TRAIL derived from neutrophils was insufficient cytotoxicity for squamous cell carcinoma cells, TRAIL from neutrophils possessed a priming effect for anti-tumor drugs or irradiation-induce cytotoxicity. These results are suggested that a combination of OK-432 and conventional therapy such as anti-tumor drugs and irradiation is a new anti-tumor strategy.
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