2011 Fiscal Year Final Research Report

Effect of Concomitant use of G-CSF in bone regeneration by CD34 positive cells.

Research Project

Project/Area Number	21592579
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	Yokohama City University
Principal Investigator	OHTA Shinsuke 横浜市立大学, 医学研究科, 客員研究者 (30336581)
Co-Investigator(Kenkyū-buntansha)	TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127) MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641) MATSUI Yoshiro 香川大学, 医学部, 教授 (10181687)
Research Collaborator	ADACHI Makoto 横浜市立大学, 附属病院, 指導診療医 (10468192)
Project Period (FY)	2009 – 2011
Keywords	骨再生 / CD34 / G-CSF / 骨髄間質細胞 / 自家培養骨膜
Research Abstract	So far in the field of bone regeneration, we have used artificial bone and autologous bone. Therefore, there are some difficulties, such as invasiveness of the surgery, foreign-body reaction and space reservation. In this study, at the beginning, although we had tried to use CD34 positive stem cells derived from peripheral blood to inhibit invasiveness of method, the cells which we could obtained from peripheral blood were limited to accomplish this method in clinic. Consequently, we have tried to use the combination of artificial bone, stem cells obtained from bone marrow and periosteum. So we carried out effective new method of bone regeneration.

(1 results)