2011 Fiscal Year Final Research Report
Basic research on bone regenerative medicine using dental pulp cells and periodontal ligament cells
| Project/Area Number |
21592615
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Matsumoto Dental University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Hiroo 松本歯科大学, 総合歯科医学研究所, 教授 (90147637)
NAKAMURA Hiroshi 松本歯科大学, 歯学部, 講師 (00278178)
NAKAMICHI Yuuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 歯髄細胞 / 歯根膜細胞 / カーボンナノチューブ / 石灰化 / BMP / Wntシグナル / マウス / ヒト |
|---|
| Research Abstract |
Dental pulp cells are considered to be a promising tool for the regeneration of hard tissues, due to their multipotency. Mouse dental pulp cells exhibited strong alkaline phosphatase and extracellular matrix calcification activity even in the absence of exogenous rhBMP-2.The transplanted dental pulp cells into immunodeficiency mice exert bone regenerative activity in vivo. In addition, human dental pulp cells also exhibited strong alkaline phosphatase and extracellular matrix calcification activity.
|
