2011 Fiscal Year Final Research Report
The development of a new therapy for periodontitis by regulation of TNF family members
| Project/Area Number |
21592628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Motoharu 鹿児島大学, 大学院・医歯学総合研究科, 助教 (50452941)
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| Project Period (FY) |
2009 – 2011
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| Keywords | TNFファミリー / 歯周病 / 治療薬 / TACE阻害剤 / エピガロカテキンガレート |
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| Research Abstract |
TNF-α is a proinflamatory cytokine, plays a pivotal role in the inflammatory reaction. Its precursor is cleaved by a metalloprotease named TNF-α-converting enzyme(TACE) to generate the mature TNF-α. The aim of this study is to generate a potent anti-inflammatory drug, TACE inhibitor and epigallocatechin 3 gallate(EGCG) to periodontitis where TNFα is thought to be pathologically indicated. TACE immunopositively localized mainly in macrophages and gingival fibroblast in inflamed human gingival tissues. The TACE inhibitor and EGCG eliminated kinetics of LPS-induced TNF-α secretion in a dose-dependent manner by ELISA. Furthermore, EGCG showed more strong inhibitory effect under high glucose conditions. TACE reduced alveolar bone loss in a rat model of P. gingivalis-induced periodontitis. TACE inhibitor and EGCG appear to be an attractive target for treating human periodontitis.
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