Effect of the IL-1 typeIIreceptor to a experimental periodontitis infected with periodontal bacterium

2011 Fiscal Year Final Research Report

• Project/Area Number: 21592638
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: ISHIHARA Yuichi 愛知学院大学, 歯学部, 准教授 (50261011)
• Co-Investigator(Kenkyū-buntansha): MITANI Akio 愛知学院大学, 歯学部, 講師 (50329611) ; KAMEI Hidehiko 愛知学院大学, 歯学部, 講師 (50421243)
• Project Period (FY): 2009 – 2011
• Keywords: 歯周免疫機能学 / インターロイキン-1 / 実験的歯周炎 / インターロイキン-1タイプIIレセプター / インターロイキン-1レセプターアンタゴニスト

Research Abstract

Experimental periodontosis model animal was changed to a rat from a mouse, and experimental periodontosis was induced by periodontal bacterium-adhered ligature onto the molars at 2009 and 2010.The experimental site observed the high levels of inflammatory cytokine production, the inflammatory bone resorption with osteoclast formation and IL-1R2 and IL-1Ra inhibited the osteoclast differentiation factors from rat osteoblast. The research will be developed in 2011 using an IL-1Ra gene deficient mouse.

Research Products

• [Journal Article] Regulation of type 17 helper T-cell function by nitric oxide during inflammation (2011)
  • Author(s): Niedbala W, Alves-Filho JC, Fukada SY, Vieira SM, Mitani A, Sonego F, Mirchandani A, Nascimento DC, Cunha FQ, Liew FY
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 9220-9225
  • Peer Reviewed
• [Journal Article] Azithromycin may inhibit interleukin-8 through suppression of Rac1 and a nuclear factor-kappa B pathway in KB cells stimulated with lipopolysaccharide (2011)
  • Author(s): Matsumura Y, Mitani A, Suga T, Kamiya Y, Kikuchi T, Tanaka S, Aino M, Noguchi T
  • Journal Title: J Periodontol Volume: 82 Pages: 1623-1631
  • Peer Reviewed
• [Journal Article] Valproic Acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 1 (2011)
  • Author(s): Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
  • Journal Title: Shock Volume: 36 Pages: 494-500
  • Peer Reviewed
• [Presentation] IL-1Ra欠損マウスの破骨細胞形成能と実験的歯周炎について (2011)
  • Author(s): 石原裕一, 水谷大樹, 伊澤有郎, 三谷章雄, 黒須康成, 川瀬仁史, 稲垣幸司, 野口俊英
  • Organizer: 第135回日本歯科保存学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-21
• [Presentation] IL-1Ra欠損マウスを用いたA. actinomycetemcomitans単独感染による実験的歯周炎の病態と骨関連分子の遺伝子発現 (2011)
  • Author(s): 伊澤有郎, 石原裕一, 水谷大樹, 小林周一郎, 小澤佑介, 神谷洋介, 久保勝俊, 杉田好彦, 前田初彦, 野口俊英
  • Organizer: 第54回秋季日本歯周病学会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-24
• [Presentation] IL-1RaKOマウス腹腔マクロファージを用いた破骨細胞形成能と骨吸収活性の解析 (2011)
  • Author(s): 水谷大樹, 石原裕一, 藤原祐子, 伊澤有郎, 小澤佑介, 神谷洋介, 近藤久貴, 西原達次, 戸刈彰史, 野口俊英
  • Organizer: 第54回秋季日本歯周病学会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-24
• [Presentation] IL-1Ra欠損マウス腹腔マクロファージにおける骨吸収活性の解析 (2011)
  • Author(s): 水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 久保勝俊, 西原達次, 前田初彦, 野口俊英
  • Organizer: 第3回口腔先端応用医科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-22
• [Presentation] ラット実験的歯周炎における破骨細胞形成とIL-1ファミリーの動態 (2010)
  • Author(s): 小澤佑介, 石原裕一, 水谷大樹, 伊澤有郎, 亀井英彦, 田中繁寿, 林潤一郎、三谷章雄, 神谷洋介, 西原達次, 前田初彦, 野口俊英
  • Organizer: 第53回秋季日本歯周病学会
  • Place of Presentation: 高松
  • Year and Date: 2010-09-19
• [Presentation] IL-1RaKOマウス腹腔マクロファージからのIL-1産生亢進 (2010)
  • Author(s): 水谷大樹, 石原裕一, 伊澤有郎, 小澤佑介, 相野誠、神谷洋介, 亀井英彦, 田中繁寿, 三谷章雄, 西原達次, 前田初彦, 野口俊英
  • Organizer: 第53回秋季日本歯周病学会
  • Place of Presentation: 高松
  • Year and Date: 2010-09-19
• [Presentation] Interleukin-1 receptor type2 production from mouse gingival epithelial cell (2009)
  • Author(s): Y. Ishihara, Y. Kamiya, Y. Ozawa, A. Nagahara, H. Mizutani, S. Tanaka, H. Kamei, T. Noguchi
  • Organizer: The 95th annual meeting of the American Academy of Periodontology
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-09-14