2011 Fiscal Year Final Research Report
Identification of novel nerve injury-induced proteins and their roles in ion channel modulation and pain transduction
| Project/Area Number |
21600002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Hiroaki 金沢大学, 保健管理センター, 教授 (10272981)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIDA Haruhiro 金沢大学, 医学系, 教授 (30093066)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経損傷 / イオンチャネル / 痛み |
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| Research Abstract |
We explored genes whose protein products were assumed to be released into the extracellular space after axotomy of rat sciatic nerve, and identified glycoprotein non-metastatic melanoma B(Gpnmb) as a candidate. Gpnmb expression was detected in infiltrating macrophages in the nerve ends. Also, Gpnmb was expressed in microglia in the layers I and II of the spinal dorsal horn of normal rats. These results suggest that Gpnmb might be involved in the modulation of pain transduction.
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