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2011 Fiscal Year Final Research Report

Modulation of nociceptive genes by in vivo RNA interference in rats and application to pain treatment

Research Project

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Project/Area Number 21600006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionNagasaki University

Principal Investigator

TODA Kazuo  長崎大学, 医歯薬学総合研究科, 教授 (80134708)

Co-Investigator(Kenkyū-buntansha) KIMOTO Mari  日本女子大学, 家政学部, 准教授 (60101565)
Project Period (FY) 2009 – 2011
Keywords眼窩下神経結紮モデル / 三叉神経脊髄路核 / トランスフェクション / RNA干渉 / フォンフライ毛 / 外界電位 / 逃避反射 / ラット
Research Abstract

Neuropathic pain can be very difficult to treat. It may be associated with abnormal sensations called dysesthesia, and pain is produced by normally non-noxious stimuli(allodynia). Recently, it is reported that nociceptive-genes are strongly concerned with producing neuropathic pain and inhibition of nocicptive-gene expression is one of the tools to treat neuropathic pain. This study revealed that inhibition of nocicptive-genes by in vivo RNA interference elevated threshold value to mechanical noxious stimuli.

  • Research Products

    (11 results)

All 2012 2011 2010 2009

All Journal Article (3 results) Presentation (6 results) Book (2 results)

  • [Journal Article] Hypergravity conditioning on ileal movements in rats2012

    • Author(s)
      Kimoto M, Zeredo JL, Toda K
    • Journal Title

      Aviation, Space and Environmental Medicine

      Volume: (in press)

  • [Journal Article] Irritant-drinking Behaviour can be Modifi ed by gravity-stress loaded in developing but not in adult rats2011

    • Author(s)
      Kimoto M, Zeredo JL, Toda K
    • Journal Title

      Stress and Health

      Volume: 27 Pages: 34-41

  • [Journal Article] Response properties of nucleus reticularis lateralis neurons after electroacupuncture stimulation in rats2010

    • Author(s)
      Moritaka K, Zeredo JL, Kimoto M, Nasution FH, Hirano T, Toda K
    • Journal Title

      Am J Chin Med

      Volume: 38(5) Pages: 869-80

  • [Presentation] Antinociceptive effects induced by gravity stress in rats : Sex differences2011

    • Author(s)
      Toda K, Zeredo JL, Moritaka K, Yamashita H, Kaida K, Kimoto M
    • Organizer
      43rd Meeting of the European Brain and Behavior Society(EBBS)
    • Place of Presentation
      Seville, Spain
    • Year and Date
      20110909-12
  • [Presentation] Comparison of stress-induced modulation of smooth muscle activities between small and large intestine in adult rats2011

    • Author(s)
      Kimoto M, Ikezaki M, Kato M, Kohata A, Takashima K, Takeuchi M, Nemoto S, Zeredo JL, Toda K
    • Organizer
      43rd Meeting of the European Brain and Behavior Society(EBBS)
    • Place of Presentation
      Seville, Spain
    • Year and Date
      20110909-12
  • [Presentation] Signaling pathway in extracellular calcium sensing of frog parathyroid cells2011

    • Author(s)
      Okada Y, Miyazaki T, Hotokezaka H, Fujiyama R, Toda K
    • Organizer
      ICCPB2011
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20110531-0605
  • [Presentation] Stress-induced modulation of ileal peristaltic movement in rats2010

    • Author(s)
      Kimoto M, Kumei Y, Zeredo JL, Toda K
    • Organizer
      7th World Congress on Stress, Leiden
    • Place of Presentation
      The Netherlands
    • Year and Date
      20100825-27
  • [Presentation] Trigeminal irritant-induced behavior can be modified by gravity stress in younger rats, EFIC-conferences2009

    • Author(s)
      Kimoto M, Zeredo JL, Kumei Y, Toda K
    • Organizer
      Pain in Europe VI
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      20090909-12
  • [Presentation] Nociceptive behaviors in rats at low gravity conditions, EFIC-conferences2009

    • Author(s)
      Ishida, T, Zeredo JL, Yabushita T, Seki S, Fusejima Y, Fukushima G, Toda K, Kumei Y
    • Organizer
      Pain in Europe VI
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2009-09-12
  • [Book] 基礎解剖生理学第3版2011

    • Author(s)
      戸田一雄,木本万里
    • Total Pages
      1-449
    • Publisher
      おうふう出版
  • [Book] はじめての痛み学2011

    • Author(s)
      植田弘師,戸田一雄
    • Total Pages
      1-170
    • Publisher
      おうふう出版

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Published: 2013-07-31  

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