2012 Fiscal Year Final Research Report
Elucidation of the mechanism underlying the suppression of the development of analgesic tolerance to morphine under chronic pain
| Project/Area Number |
21600012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
TAN-NO Koichi 東北薬科大学, 薬学部, 教授 (20207260)
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| Project Period (FY) |
2009 – 2012
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| Keywords | モルヒネ / 鎮痛耐性 / 身体的依存 / 慢性疼痛 / 一酸化窒素 / ホルマリン試験 / マウス |
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| Research Abstract |
This study examined the mechanism underlying suppression of analgesic tolerance to morphine under chronic pain condition. Chronic pain was induced by intraplantar injection of 1% formalin, which significantly suppressed the development of analgesic tolerance to morphine. The formalin-induced suppression of analgesic tolerance to morphine was significantly reversed by L-arginine, a precursor of nitric oxide, but not by D-arginine. These results suggest that suppression of analgesic tolerance to morphine under formalin-induced pain may be mediated through the inhibition of nitric oxide production.
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[Journal Article] Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice2010
Author(s)
Tan-No K., Sato T., Shimoda M., Nakagawasai O., Niijima F., KawamuraS., Furuta S., Sato T., Satoh S., Silberring J., Terenius L., Takeshi Tadano
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Journal Title
Neuropeptides
Volume: 44
Pages: 279-283
DOI
Peer Reviewed
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