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2012 Fiscal Year Final Research Report

Elucidation of the mechanism underlying the suppression of the development of analgesic tolerance to morphine under chronic pain

Research Project

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Project/Area Number 21600012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionTohoku Pharmaceutical University

Principal Investigator

TAN-NO Koichi  東北薬科大学, 薬学部, 教授 (20207260)

Project Period (FY) 2009 – 2012
Keywordsモルヒネ / 鎮痛耐性 / 身体的依存 / 慢性疼痛 / 一酸化窒素 / ホルマリン試験 / マウス
Research Abstract

This study examined the mechanism underlying suppression of analgesic tolerance to morphine under chronic pain condition. Chronic pain was induced by intraplantar injection of 1% formalin, which significantly suppressed the development of analgesic tolerance to morphine. The formalin-induced suppression of analgesic tolerance to morphine was significantly reversed by L-arginine, a precursor of nitric oxide, but not by D-arginine. These results suggest that suppression of analgesic tolerance to morphine under formalin-induced pain may be mediated through the inhibition of nitric oxide production.

  • Research Products

    (14 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice2013

    • Author(s)
      Nemoto W ., Sato T ., Nakagawasai O., Yaoita F ., Silberring J., Tadano T , Tan-No K
    • Journal Title

      Neuropeptides

      Volume: 47 Pages: 187-191

    • DOI

      doi:10.1016/j.npep.2012.11.002

    • Peer Reviewed
  • [Journal Article] モルヒネの鎮痛耐性および身体的依存形成におけるシステインプロテアーゼの関与2011

    • Author(s)
      丹野孝一
    • Journal Title

      東北薬科大学研究誌

      Volume: 58号 Pages: 29-34

    • URL

      http://ci.nii.ac.jp/vol_issue/nels/AA1149311X_jp.html

    • Peer Reviewed
  • [Journal Article] Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism2011

    • Author(s)
      Watanabe S., Tan-No K., Tadano T., Higashi H
    • Journal Title

      Pain

      Volume: 152 Pages: 327-334

    • DOI

      doi:10.1016/j.pain.2010.10.036

    • Peer Reviewed
  • [Journal Article] Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice2010

    • Author(s)
      Tan-No K., Sato T., Shimoda M., Nakagawasai O., Niijima F., KawamuraS., Furuta S., Sato T., Satoh S., Silberring J., Terenius L., Takeshi Tadano
    • Journal Title

      Neuropeptides

      Volume: 44 Pages: 279-283

    • DOI

      doi:10.1016/j.npep.2010.02.001

    • Peer Reviewed
  • [Journal Article] Nociceptive behavior induced by the endogenous opioid peptides dynorphins in uninjured mice: evidence with intrathecal N-ethylmaleimide inhibiting dynorphin degradation2009

    • Author(s)
      Tan-No K., Takahashi H., NakagawasaiO., Niijima F., Sakurada S., Bakalkin G., Terenius L., Tadano T
    • Journal Title

      Int. Rev. Neurobiol

      Volume: 85 Pages: 191-205

    • DOI

      doi:10.1016/S0074-7742(09)85015-0

    • Peer Reviewed
  • [Presentation] 脊髄疼痛伝達機構におけるアンジオテンシンII の役割について2013

    • Author(s)
      根本亙,中川西修,八百板富紀枝,三浦圭裕,長谷川大地,大友光平,大堀彩,岡本駿,只野武,丹野孝一
    • Organizer
      平成 25 年度東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      20130500
  • [Presentation] Gangliosides produce nociceptive behavior and hyperalgesia via glutamate signals2013

    • Author(s)
      Watanabe S., Tan-No K., Tadano T., HigashiH
    • Organizer
      International Symposium for Neurosciences201
    • Place of Presentation
      仙台
    • Year and Date
      20130300
  • [Presentation] Angiotensin II induces nociceptive behavior accompanied by p38 MAPK phosphorylation mediated through spinal AT1 receptors2013

    • Author(s)
      Nemoto W., Nakagawasai O., Yaoita F., Kanno S., Yomogida S., Ishikawa M., TadanoT., Tan-No K
    • Organizer
      International Symposium for Neurosciences2013
    • Place of Presentation
      仙台
    • Year and Date
      20130300
  • [Presentation] アンジオテンシン II 誘発性疼痛関連行動における p38 MAPK の関与2012

    • Author(s)
      根本亙,中川西修,八百板富紀枝,菅野秀一,蓬田伸,石川正明,只野武,丹野孝一
    • Organizer
      第63回日本薬理学会北部会
    • Place of Presentation
      新潟
    • Year and Date
      20120900
  • [Presentation] Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphin2011

    • Author(s)
      Tan-No K., Shimoda M., Watanabe K., Nakagawasai O., Yaoita F., Kanno S., Ishikawa M., Bakalkin G., Tadano T
    • Organizer
      Italian-Japanese International Seminar for Neurosciences
    • Place of Presentation
      仙台
    • Year and Date
      20110900
  • [Presentation] アンジオテンシンII脊髄クモ膜下腔内投与による疼痛関連行動2010

    • Author(s)
      鈴木義紀,丹野孝一,中川西修,新島富紀枝,菅野秀一,蓬田 伸,石川正明,只野武
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      郡山
    • Year and Date
      20101000
  • [Presentation] Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia2010

    • Author(s)
      Watanabe S., Tan-No K., Tadano T., Higashi H
    • Organizer
      Molecular Targets for Novel Pain Therapeutics. From Basic Research to Clinical Translation
    • Place of Presentation
      Calabria (Italy)
    • Year and Date
      20100900
  • [Presentation] モルヒネ鎮痛耐性軽減薬の探索研究-慢性疼痛患者の QOL 向上を目指して-2009

    • Author(s)
      丹野孝一,下田将司,中川西修,新島富紀枝,菅野秀一,石川正明,只野武
    • Organizer
      第37回薬物活性シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      20091000
  • [Remarks]

    • URL

      http://www.tohoku-pharm.ac.jp/laboratory/yakuri/index.html

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Published: 2014-08-29  

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