2011 Fiscal Year Final Research Report
Development of the gene therapy against the morphine-resistant intractable pain using endomorphin precursor
| Project/Area Number |
21600013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKURADA Shinobu 東北薬科大学, 薬学部, 教授 (30075816)
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| Project Period (FY) |
2009 – 2011
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| Research Abstract |
We found the DNA fragments which theoretically can synthesize endomorphin-1(EM-1) and endomorphin-2(EM-2). The reduction of this DNA fragment, observed in a neuropathic pain state, revealed the reduction of pain threshold. On the other hand, unlike morphine, EM-1 and EM-2 showed potent analgesic effect against neuropathic pain. Moreover, theμ-opioid receptor splice variants sensitive to EM-1 and EM-2 retained in a neuropathic pain state. The results provide the information for the development of the gene therapy against the morphine-resistant intractable pain using endomorphin precursor.
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[Journal Article] Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Neurosci. Lett
Volume: 495
Pages: 83-87
DOI
Peer Reviewed
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[Journal Article] Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally2011
Author(s)
H. Mizoguchi, T. Komatsu, Y. Iwata, C. Watanabe, H. Watanabe, T. Orito, S. Katsuyama, A. Yonezawa, K. Onodera, T. Sakurada, S. Sakurada
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Journal Title
Eur. J. Pharmacol
Volume: 653
Pages: 21-25
DOI
Peer Reviewed
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[Journal Article] Lack of a rewarding effect and a locomotor-enhancing effect of the selectiveμ-opioid receptor agonist amidino-TAPA2010
Author(s)
H. Mizoguchi, C. Watanabe, S. Osada, M. Yoshioka, Y. Aoki, S. Natsui, A. Yonezawa, S. Kanno, M. Ishikawa, T. Sakurada, S. Sakurada
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Journal Title
Psychopharmacology
Volume: 212
Pages: 215-225
DOI
Peer Reviewed
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