2011 Fiscal Year Final Research Report
Molecular design of amylase inhibitor based on the substrate recognition property of the enzyme
| Project/Area Number |
21603001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAWABATA Jun 北海道大学, 大学院・農学研究院, 教授 (60142197)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Eisuke 北海道大学, 大学院・農学研究院, 教授 (40466446)
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| Project Period (FY) |
2009 – 2011
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| Keywords | α-アミラーゼ / 酵素阻害剤 / 糖尿病 / 分子設計 / グルコシダーゼ阻害剤 |
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| Research Abstract |
Inhibition of the pancreaticα-amylase is useful for the treatment of obesity and diabetes mellitus. However, not many small molecule inhibitors are known for this enzyme due to its characteristic substrate recognition which recognizes chained glucoses. We used this characteristic mode of substrate recognition to design new small moleculeα-amylase inhibitors and synthesized them. These synthetic inhibitors revealed a useful property of the pancreaticα-amylase for further development of the inhibitor.
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