Dose evaluation for stem cell lineages

2011 Fiscal Year Final Research Report

• Project/Area Number: 21611010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: Japan Atomic Energy Agency
• Principal Investigator: KINASE Sakae 独立行政法人日本原子力研究開発機構, 安全研究センター, 研究主幹 (70354701)
• Project Period (FY): 2009 – 2011
• Keywords: 幹細胞 / ドジメトリ / 線量 / ボクセル / 階層化 / モンテカルロ / マウス

Research Abstract

To develop stem cell dosimetry in the field of radiation effect, a three-dimensional organ voxel model that allowed for the dose calculation of stem cells(basal cells), was developed. In addition, a Monte Carlo simulation system that consists of two codes-an electromagnetic cascade code and a track-structure code, was developed to evaluate absorbed doses for stem cell lineages as well as radical yield by radiation. Furthermore, interspecies scaling factors of self-organ dose from the voxel mouse to the voxel human were studied.