2011 Fiscal Year Final Research Report
transcranial direct current stimulation : a potential treatment of depression
| Project/Area Number |
21659274
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KITAHARA Yuichi 山梨大学, 大学院・医学工学総合研究部, 助教 (00436859)
FUJII Tomokazu 山梨大学, 大学院・医学工学総合研究部, 助教 (30456454)
YASUDA Kazuyuki 山梨大学, 医学部・附属病院, 助教 (90456442)
YAMAGUCHI Masayasu 山梨大学, 医学部・附属病院, 医員 (90568263)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神生理学 |
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| Research Abstract |
The effects of repeated transcranial direct current stimulation(tDCS) on mood and neurocognitive function were investigated by applying anodal stimulation over the left dorsolateral prefrontal cortex(DLPFC). We recruited healthy male participants for this single-blind, sham-controlled crossover trial. We used Profile of Mood States, brief-form(POMS) and CogHealth to evaluate the changes in mood and neurocognitive function, respectively, before, and immediately after4-daily anodal or sham tDCS. While there were no significant changes in six factors of POMS and performance(speed and accuracy) of CogHealth between sham and anodal stimulation, accuracy of a visual recognition memory task was increased at the end of experiment. Furthermore, these changes were pronounced in the group started with anodal stimulation. These results suggest that4-daily anodal tDCS over left DLPFC might improve visual recognition learning without deleterious effects in healthy subjects and further support the view that tDCS is a potential treatment of depression.
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[Journal Article] 電気けいれん療法(ECT)のわが国での現況:全国実態調査の結果から総合病院精神科に求められること2010
Author(s)
奥村正紀, 鮫島達夫, 粟田主一, 鹿島晴雄, 本橋伸高, 澤温, 和田健, 分島徹, 川嵜弘詔, 中村満, 山口成良, 一瀬邦弘, 大久保善朗
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Journal Title
総合病院精神医学
Volume: 22
Pages: 105-118
Peer Reviewed
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