2011 Fiscal Year Final Research Report
Development of artificial antibodies to molecular targets of cancer cells
| Project/Area Number |
21659306
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kawasaki Medical School (2011)
Kyushu University (2009-2010) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 外科総論 |
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| Research Abstract |
The goal of the study is designing a peptide affinity for cancer-related molecule. To validate the anti-tumor effect, subject to the(Hh) signal Hedgehog, Small peptides with affinity for cell surface receptor Ptched1 were designated. Its effect on cancer cells were examined using breast and pancreatic cancer cells. We probed that synthesized peptides suppressed Hh signaling activity and cancer cell proliferation in vitro and vivo.
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