2011 Fiscal Year Final Research Report

Detection and identification of Candida species in oral mucosal lesions for new oral care treatment

Research Project

Project/Area Number	21659483
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Social dentistry
Research Institution	Tohoku University
Principal Investigator	SASANO Takashi 東北大学, 大学院・歯学研究科, 教授 (10125560)
Co-Investigator(Kenkyū-buntansha)	SUGAWARA Yumiko 東北大学, 病院, 助教 (30235866) MIKIKO Saitou 新潟大学, 医歯学系, 助教 (90401760) SAKAI Azusa 東北大学, 病院, 医員 (90463778) SATO Kyoko 東北大学, 病院, 医員 (80547266) SHOJI Noriaki 東北大学, 病院, 講師 (70250800)
Project Period (FY)	2009 – 2011
Keywords	カンジダ菌種 / 口腔粘膜疾患 / 口腔ケア / 口腔扁平苔癬
Research Abstract	Candida species were detected and identified in samples from the buccal mucosa, dorsal surface of the tongue and supragingival plaque of subjects with oral lichen planus(OLP). The Candida in the samples were cultured on selection agars, and identified by sequence analyses of 18S, 5. 8S and 25/28S rRNA. The isolation frequency of Candida was higher in subjects with OLP than in those with healthy oralmucosa. Non-C. albicans were only isolated from people with OLP. These results support the notion that subjects with OLP are more likely to have oral colonization with Candida, and that non-C. albicans are specifically present in subjects with this condition.

(2 results)