2013 Fiscal Year Final Research Report
Microscopic analysis based on the quantitative behavioral tests in rodents for identification of the molecular target of developmental neurotoxicity
| Project/Area Number |
21671002
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University (2013)
The University of Tokyo (2009-2012) |
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Principal Investigator |
KAKEYAMA Masaki 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30353535)
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| Project Period (FY) |
2009 – 2013
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| Keywords | 有害化学物質 / 神経科学 / 解剖学 / 行動学 / 環境政策 |
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| Research Abstract |
The aim of this study is to develop the microscopic analysis methodology, and identify the molecular marker for developmental neurotoxicity of environmental chemicals. We found that perinatal exposure to a low dose of dioxin induces abnormal behaviors, including behavioral inflexibility, compulsive repetitive behavior, and low social dominance in mice. Immuhohistochemical analysis validated that hypoactivation of the medial prefrontal cortex (mPFC) and hyperactivation of the amygdala are the potential biological basis for these behavioral abnormalities.
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[Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage2011
Author(s)
Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M
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Journal Title
Behavioural Brain Research
Volume: 221
Pages: 172-181
DOI
Peer Reviewed
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