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2013 Fiscal Year Final Research Report

Construction and Function Emergence of Cellular Build up Wet Nano Robotics

Research Project

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Project/Area Number 21676002
Research Category

Grant-in-Aid for Young Scientists (S)

Allocation TypeSingle-year Grants
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionOsaka University (2012-2013)
Tokyo University of Agriculture and Technology (2009-2011)

Principal Investigator

MORISHIMA Keisuke  大阪大学, 工学研究科, 教授 (60359114)

Project Period (FY) 2009 – 2013
Keywordsウェットロボティクス / バイオアクチュエータ / マイクロマシン / 昆虫細胞 / 筋細胞
Research Abstract

In this study, we proposed an environmentally robust hybrid(biotic-abiotic)robotic system that uses insect cells, called"Cellular Build Up Wet Nano Robotics". In our experiments, we utilized insect cells and tissues as a mechanical component and we succeeded in demonstrating the example of a micro bioactuator and mechanical systems driven by biological components. This driving occurs autonomously at room temperature for a long time without maintenance.

  • Research Products

    (58 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (38 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Atmospheric-opera ble bioactuator powered by insect muscle2013

    • Author(s)
      Y. Akiyama, K. Funako shi, T. Hoshino, K. Iwabuchi, K. Morishima
    • Journal Title

      Lab on a Chip

      Volume: 13(24) Pages: 4870-1880

    • Peer Reviewed
  • [Journal Article] Measuring Adhesion Force of a Cell Sheet by the Ninety-degree Peel Test Using a Multi Hook Type Fixture2013

    • Author(s)
      K. Uesugi, Y. Akiyama, T. Hoshino, Y. Akiyama, M. Yamato, T. Okano, K. Morishima
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 8(2) Pages: 129-138

    • Peer Reviewed
  • [Journal Article] Bio-Manipulation Method Based on Hydrodynamic Forces of Multiple Microfluidic Streams2013

    • Author(s)
      Y. Yalikun, Y. Akiyama, T. Hoshino, K. Morishima
    • Journal Title

      Journal of Rohotics and Mechatronics

      Volume: 25(4) Pages: 611-618

    • Peer Reviewed
  • [Journal Article] Measuring mechanical properties of cell sheet by tensile test using self-attachable fixture2013

    • Author(s)
      K. Uesugi, Y. Akiyama, T. Ho shino, Y. Akiyama, M. Yamato, T. Okano, K. Morishima
    • Journal Title

      Journal of Rohotics and Mechatronics

      Volume: 25(4) Pages: 603-610

    • Peer Reviewed
  • [Journal Article] Voluntary Movement Controlled by the Surface EMG Signal for Tissue-engineered Skeletal Muscle on a Gripping Tool2013

    • Author(s)
      K. Kabumoto, T. Ho shino, Y. Akiyama, K. Morishima
    • Journal Title

      Tissue Engineering Part A

      Volume: 19(15-16) Pages: 1695-1703

    • Peer Reviewed
  • [Journal Article] Cell patteming through inkjet printing of one cell per droplet2012

    • Author(s)
      S. Yamaguchi, A. Ueno, Y. Akiyama, K. Morishima
    • Journal Title

      Biofabrication

      Volume: 4 Pages: 045005

    • DOI

      doi:10.1088/1758-5082/4/4/045005

    • Peer Reviewed
  • [Journal Article] Rapidly-moving insect muscle-powered microrobot and its chemical acceleration2012

    • Author(s)
      Y. Akiyama, K. Odaira, K. Sakiyama, T. Hoshino, K. Iwabuchi, K. Morishima
    • Journal Title

      Biomedical Microdevices

    • DOI

      DOI:10.1007/sl0544-0l2-9700-5

    • Peer Reviewed
  • [Journal Article] Room temperature operable autonomously moving bio-microrobot powered by insect dorsal vessel tissue2012

    • Author(s)
      Y. Akiyama, T. Hoshino, K. lwabuchi, and K. Morishima
    • Journal Title

      PLoS One

      Volume: 7(7) Pages: e38274

    • DOI

      DOI:10.1371/journaLpone.0038274

    • Peer Reviewed
  • [Journal Article] Cardiomyocyte-driven gel network for bio mechano-informatic wet robotics2012

    • Author(s)
      Takayuki Ho shino, Kentaro Imagawa, Yoshitake Akiyama, and Keisuke Morishima
    • Journal Title

      Biomedical Microdevices

      Volume: 14(6) Pages: 969-977

    • Peer Reviewed
  • [Journal Article] Contracting cardiomyocytes in hydrophobic room-temperature ionic liquid2012

    • Author(s)
      Takayuki Hoshino, Kyoko Fujita, Ayako Higashi, Keiko Sakiyama, Hiroyuki Ohno, and Keisuke Morishima
    • Journal Title

      Biomedical and Biophysical Research communications

      Volume: 427(2) Pages: 379-384

    • Peer Reviewed
  • [Journal Article] Electrical stimulation of cultured lepidopteran dorsal vessel tissue : an experiment for development of bioactuators2010

    • Author(s)
      Y. Akiyama, K. Iwabuchi, Y. Furukawa, Keisuke Morishima
    • Journal Title

      Developmental Biology - Animal

      Volume: vol.46 Pages: 411-415

    • Peer Reviewed
  • [Journal Article] Cell-driven Three-dimensional Manipulation of Micro-parts for a Micro-assembly2010

    • Author(s)
      T. Hoshino, A. Higashi, T. Konno, K. Ishihara, Keisuke Morishima
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol.49 Pages: 06GMO3-1-06GMO3-4

    • Peer Reviewed
  • [Journal Article] Rod-shaped Tissue Engineered Skeletal Muscle with Artificial Anchors to Utilize as a Bio-Actuator2010

    • Author(s)
      Y. Akiyama, R. Terada, M. Hashimoto, T. Ho shino, Y. Furukawa, Keisuke Morishima
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: vol. 5 Pages: 236-244

    • Peer Reviewed
  • [Journal Article] Muscle-powered Cantilever for Microtweezers with an Artificial Micro Skeleton and Rat Primary Myotubes2010

    • Author(s)
      Takayuki Hoshino, Keisuke Morishima
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: vol.5 Pages: 245-251

    • Peer Reviewed
  • [Journal Article] Fabrication and Evaluation of Reconstructed Cardiac Tissue and Application to Bio-actuated Microdevices2009

    • Author(s)
      H. Horiguchi, K. Imagawa, T. Hoshino, Y. Akiyama, Keisuke Morishima
    • Journal Title

      IEEE Transaction on Nano Bioscience

      Volume: vol.8 Pages: 349-355

    • Peer Reviewed
  • [Journal Article] Live-Cell-driven Insertion of a Nanoneedle2009

    • Author(s)
      T. Hoshino, T. Konno, K. Ishihara, Keisuke Morishima
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol.48 Pages: 107002-1-107002-6

    • Peer Reviewed
  • [Journal Article] Long-term and room temperature operable bio-actuator powered by insect dorsal vessel tissue2009

    • Author(s)
      Y. Akiyama, K. Iwabuchi, Y. Furukawa, Keisuke Morishima
    • Journal Title

      Lab on a Chip

      Volume: vol.9 Pages: 140-144

    • Peer Reviewed
  • [Presentation] Evaluation and optical control of somatic muscle micro bioactuator of transgenic drosophila melanogaster2014

    • Author(s)
      M. Hirooka, S. P. Beh, T. Asano, Y. Akiyama, T. Hoshino, K. Hoshino, H. Tsujimura, K. Iwabuchi and K. Morishima
    • Organizer
      The 27th International Conference on Micro Electro Mechanical Systems(MEMS 2014)
    • Place of Presentation
      USA
    • Year and Date
      20140100
  • [Presentation] In-air opeable biohybrid micromanipulator powered by insect heart muscle tissue2013

    • Author(s)
      Y. Akiyama, K. Funakoshi, K. Morishima
    • Organizer
      The 17th International Conference on Miniaturized Systems for Chemistry and Life Science (μTAS 2013)
    • Place of Presentation
      Freiburg (Germany)
    • Year and Date
      20131000
  • [Presentation] Room Temperature Operable Muscle-Powered Microrobot2013

    • Author(s)
      K. Morishima
    • Organizer
      The International Conference on Biomimetic and Biohybrid Systems (Living Machines 2013)
    • Place of Presentation
      London
    • Year and Date
      20130700
  • [Presentation] Visual Servo of Muscle-powered Optogenetic Bioactuator2013

    • Author(s)
      S.P.Beh. M.Hirooka, T.Hoshino, Y.Akiyama, H.Tsujimura and K. Morishima
    • Organizer
      Transducers'13, the 17th International Conference on Solid-State Sensors, Actuators, and Microsystems and, Catalonia
    • Place of Presentation
      Spain
    • Year and Date
      20130600
  • [Presentation] Emergent Functionality of Cellular Buildup Wet Robotics2012

    • Author(s)
      K. Morishima
    • Organizer
      CIMTEC 2012
    • Year and Date
      20120600
  • [Presentation] Chemical Switching of Micro Jellyfish-Shaped Robot Consisting Only of Cardiomyocyte Gel2011

    • Author(s)
      R. Takemura, Y. Akiyama, T. Hoshino, K. Morishima
    • Organizer
      The 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2011)
    • Place of Presentation
      IEEE
    • Year and Date
      20110600
  • [Presentation] Construction of Mechano-Bionic System using an Environmentally robust Insect Muscle Tissue2011

    • Author(s)
      K. Morishima, Takayuki Hoshino Y. Akiyama
    • Organizer
      The 2011 IEEE International Conference on Robotics and Automation(ICRA 2011)
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      20110500
  • [Presentation] Emergent functionality of regenerative biomechanical systems powered by muscle cells toward wet nano-robotics2011

    • Author(s)
      K. Morishima
    • Organizer
      Workshop "Medical micro-robots : potential, challenges, strategies and dreams
    • Place of Presentation
      The Center for Micro-BioRobotics IIT@SSSA
    • Year and Date
      20110300
  • [Presentation] A Light Regulated Bio-Micro-Actuator Powered by Transgenic Drosophila Melanogaster Muscle Tissue2011

    • Author(s)
      K Suzumura, K Funakoshi, Takayuki Hoshino, K Iwabuchi, Y Akiyama, H Tsujimura, K. Morishima
    • Organizer
      The 24th International Conference on Micro Electro Mechanical Systems (MEMS 2011)
    • Place of Presentation
      Cancun (Mexico)
    • Year and Date
      20110123-27
  • [Presentation] 細胞ビルドアップ型ウエットナノロボティクスの構築と機能創発2011

    • Author(s)
      森島圭祐
    • Organizer
      日本機械学会 安全・安心な社会を支える運動と振動の制御 研究分科会
    • Year and Date
      20110100
  • [Presentation] Long-term and Room Temperature Operable Bio-microrobot Powered by Insect Hear Tissue2011

    • Author(s)
      Y. Akiyama, K. Odaira, K. Iwabuchi, K. Morishima
    • Organizer
      The 24th International Conference on Micro Electro Mechanical Systems (MEMS2011)
    • Place of Presentation
      Cancun (Mexico)
    • Year and Date
      20110100
  • [Presentation] 生命機械融合ウェットロボティクスの創製2011

    • Author(s)
      森島圭祐
    • Organizer
      第72回阪大融合技術懇談会
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2011-11-01
  • [Presentation] Optical Controlled Microfluidic Components By Optogentetic Bioactuator2011

    • Author(s)
      Takayuki Hoshino, Kiyofumi Suzumura, Taichi Kimura, Kei Funakoshi, Yoshitake Akiyama, Hidenobu Tsujimura, Kikuo Iwabuchi, and Keisuke Morishima
    • Organizer
      The 15th International Conference on Miniaturized Systems for Chemistry and Life Science (μTAS 2011)
    • Place of Presentation
      Seattle (U.S.A.)
    • Year and Date
      2011-10-05
  • [Presentation] Construction and Function Emergence of Cellular Build up Wet Nano Robotics2010

    • Author(s)
      K. Morishima
    • Organizer
      9th iCeMS International Symposium : "Mesoscale Control and Engineering of Self-Organized and Excitable Systems in Biology and Chemistry," Institute for Integrated Cell-Material Sciences(iCeMS)
    • Place of Presentation
      Kyoto University
    • Year and Date
      20101200
  • [Presentation] Design and Fabrication of Temperature-Tolerant Micro Bio-Robot Driven by Insect Heart Tissue2010

    • Author(s)
      Y. Akiyama, T. Hoshino, K. Iwabuchi, K. Morishima
    • Organizer
      The 22th International Symposium on Micro-NanoMechatronics and Human Science (MHS 2010)
    • Place of Presentation
      Nagoya (Japan)
    • Year and Date
      20101100
  • [Presentation] Construction and Function Emergence of Cellular Build up Wet Nano Robotics2010

    • Author(s)
      K. Morishima
    • Organizer
      日本一フランス先端工学シンポジウム(JFFOE)
    • Place of Presentation
      独立行政法人科学技術振興機構、フランス高等教育研究省
    • Year and Date
      20101000
  • [Presentation] 細胞ビルドアップウェットナノロボティクスの構築と機能創発2010

    • Author(s)
      森島圭祐
    • Organizer
      分子系の複合電子機能第181委員会第9回研究会
    • Year and Date
      20101000
  • [Presentation] Construction and Function Emergence of Cellular Build up Wet Nano Robotics2010

    • Author(s)
      K. Morishima
    • Organizer
      59th ICAT/JTTAS Joint International Smart Actuator Symposium,
    • Place of Presentation
      International Center for Actuators and Transducers (ICAT), Materials Research Institute (MRI) The Pennsylvania State University
    • Year and Date
      20101000
  • [Presentation] Fabrication of Room Temperature Operable Micropump Powered by Insect Muscle Cell Sheet2010

    • Author(s)
      K. Shimizu, Y. Akiyama, T. Hoshino, K. Iwabuchi, Y. Akiyama, M. Yamato, T. Okano, K. Morishima
    • Organizer
      The 14th International Conference on Miniaturized Systems for Chemistry and Life Science (μTAS 2010)
    • Place of Presentation
      Groningen (Netherland)
    • Year and Date
      20101000
  • [Presentation] Micro-encapsulation of Bio-actuator using Insect Dorsal Vessel2010

    • Author(s)
      Y. Touyama, T. Hoshino, K. Iwabuchi, K. Morishima
    • Organizer
      2009 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2009 & Micro-Nano Global COE)
    • Place of Presentation
      IEEE
    • Year and Date
      20101000
  • [Presentation] Construction of an Environmentally Robust Mechano-Bionic Actuator Using Insect Muscle Cells2010

    • Author(s)
      K. Morishima, Y. Akiyama, K. Iwabuchi
    • Organizer
      The 12th International Conference on New Actuators & 6th international Exhibition on Smart Actuators and Drive System (ACTUATOR 2010)
    • Place of Presentation
      Bremen (Germany)
    • Year and Date
      20100600
  • [Presentation] 細胞ビルドアップウェットロボティクスの創製2010

    • Author(s)
      森島圭祐, 星野隆行
    • Organizer
      リズム現象の研究会V
    • Year and Date
      20100500
  • [Presentation] 柔らかい機械をつくる-筋細胞を用いたバイオアクチュエータの応用-2010

    • Author(s)
      森島圭祐
    • Organizer
      「復元力応用分科会」第9回講演会, 日本ばね学会
    • Year and Date
      20100500
  • [Presentation] 細胞ビルドアップ型ソフトマシンの構築と機能創発2010

    • Author(s)
      森島圭祐
    • Organizer
      バイオ・マイクロシステム研究会「バイオ極限計測と細胞マイクロシステムの最先端」
    • Year and Date
      20100100
  • [Presentation] 筋細胞によるメカノケミカルカップリング型バイオアクチュエータに関する研究2010

    • Author(s)
      森島圭祐
    • Organizer
      第3回国際シンポジウム「ブレイクスルーを生み出す次世代アクチュエータ」
    • Place of Presentation
      MEXT Grant-in-Aid for Scientific Research on Priority Areas
    • Year and Date
      20100100
  • [Presentation] 細胞ビルドアップ型ウエットロボティクスの創製2010

    • Author(s)
      森島圭祐
    • Organizer
      第22回バイオエンジニアリング講演会「筋細胞のバイオエンジニアリング」,
    • Place of Presentation
      日本機械学会 vol. 09-55
    • Year and Date
      20100100
  • [Presentation] Construction and Function Emergence of Cellular Build up Wet Nano Robotics toward Quasi-Living Actuator2009

    • Author(s)
      森島圭祐
    • Organizer
      第4回人工筋肉コンファレンス-生体模倣、人工筋肉とナノバイオに関する第5回国際会議-, 産総研セルエンジニアリング研究部門
    • Place of Presentation
      産総研関西センター, 理研基幹研究所
    • Year and Date
      20091100
  • [Presentation] Single Cell Driven Nano Tweezers2009

    • Author(s)
      T. Hoshino, H. Kuroda, R. Kometani, T. Konno, K. Ishihara, K. Morishima
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2009)
    • Place of Presentation
      The Chemical Biological Microsystems Society
    • Year and Date
      20091100
  • [Presentation] Cell-driven Micro Locomotion of Micro-parts for Micro assembly2009

    • Author(s)
      T. Hoshino, K. Morishima
    • Organizer
      2009 International Microprocesses and Nanotechnology Conference (MNC 2009)
    • Year and Date
      20091100
  • [Presentation] 細胞ビルドアップ型ウエットロボティクスの構築と機能創発2009

    • Author(s)
      森島圭祐
    • Organizer
      第29回表面科学学術講演会
    • Place of Presentation
      社団法人日本表面科学会
    • Year and Date
      20091000
  • [Presentation] 細胞ビルドアップ型ウエットナノロボティクスの構築2009

    • Author(s)
      森島圭祐
    • Organizer
      平成21年度日本生物工学会年次大会 シンポジウム「生物と機械の融合-バイオロボティクス-」
    • Place of Presentation
      社団法人日本生物工学会
    • Year and Date
      20090900
  • [Presentation] 細胞ビルドアップ型ウエットナノロボティクスの創製2009

    • Author(s)
      森島圭祐
    • Organizer
      日本機械学会2009年度年次大会, 先端技術フォーラム「ナノ・マイクロロボットメカトロニクスの最前線」
    • Place of Presentation
      社団法人日本機械学会
    • Year and Date
      20090900
  • [Presentation] 昆虫の筋肉を利用した生命機械システムの構築2009

    • Author(s)
      森島圭祐
    • Organizer
      日本機械学会ロボメカ部門バイオロボティクス研究会第2回特別講演会「生物を利用したロボット」
    • Place of Presentation
      日本機械学会
    • Year and Date
      20090900
  • [Presentation] Fabrication of Insect Muscle-Powered Sheet toward Wet NanoRobotics2009

    • Author(s)
      K. Morishima, Y. Sakuma, Y. Akiyama, T. Hoshino, Y. Akiyama, M. Yamato, T. Okano
    • Organizer
      9th IEEE Conference on Nanotechnology : IEEE NANO 2009, IEEE
    • Year and Date
      20090700
  • [Presentation] Muscle-powered Nano Mechanical System Assembled by Optical Tweezers2009

    • Author(s)
      T. Hoshino, H. Kuroda, R. Kometani, T. Konno, K. Ishihara, K. Morishima
    • Organizer
      9th IEEE Conference on Nanotechnology : IEEE NANO 2009
    • Place of Presentation
      IEEE
    • Year and Date
      20090700
  • [Presentation] Quasi-Living Actuator toward Regenerative Biorobotic Systems2009

    • Author(s)
      K. Morishima
    • Organizer
      Sweden-Japan Joint Colloquium on "Frontiers in Nanobiotechnology from Engineering to Application for Cells
    • Place of Presentation
      Stockholm, Sweden, 独立行政法人日本学術振興会
    • Year and Date
      20090600
  • [Presentation] Fabrication of a Controllable Bio-Micropump Driven by Skeletal Muscle Cells2009

    • Author(s)
      T. Kogure, Y. Akiyama, T. Hoshino, K. Morishima
    • Organizer
      The 15th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2009)
    • Place of Presentation
      IEEE
    • Year and Date
      20090600
  • [Presentation] Autonomous Beating and Fluid Pumping Gel by Cardiomycytes Drug Stimulation2009

    • Author(s)
      K. Imagawa, H. Horiguchi, K. Ikeda, Y. Akiyama, T. Hoshino, S. Maruo, K. Morishima
    • Organizer
      The 15th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2009)
    • Place of Presentation
      IEEE
    • Year and Date
      20090600
  • [Book] 筋細胞ビルドアップ型バイオアクチュエータの開発, 樋口俊郎,大岡昌博編『アクチュエータ研究開発の最前線』2011

    • Author(s)
      森島圭祐,秋山佳丈
    • Total Pages
      231-238
    • Publisher
      NTS出版
  • [Book] 3次元細胞ビルドアップ型バイオアクチュエータの創製, 未来を動かすソフトアクチュエータ―高分子・生体材料を中心とした研究開発―監修長田義仁,田口隆久2010

    • Author(s)
      森島圭祐
    • Total Pages
      299-312
    • Publisher
      シーエムシー出版
  • [Remarks]

    • URL

      http://www-live.mech.eng.osaka-u.ac.jp/

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Published: 2015-03-12  

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