2010 Fiscal Year Final Research Report
Molecular behavior in non-equilibrium and asymmetric domains formed in supported planar lipid bilayers
| Project/Area Number |
21685004
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical chemistry
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| Research Institution | Toyohashi University of Technology (2010)
Institute for Molecular Science (2009) |
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Principal Investigator |
TERO Ryugo Toyohashi University of Technology, エレクトロニクス先端融合研究所, 特任助教 (40390679)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 一分子計測 / 脂質 / 表面・界面物性 |
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| Research Abstract |
Molecular diffusion behavior in supported planar lipid bilayers at submicron regions were observed in situ, and controlled using nanostructures on solid substrates. I constructed a fluorescence microscope for single molecule tracking at the spatiotemporal order over millisecond / 100 nm to second/μm, and achieved the single molecule tracking on opaque substrates and high-refractive substrates such as silicon and titanium dioxide. In situ observation of lipid diffusion at 2000 fps to 33 fps revealed that surface nanostructures on the substrates induced anomalous diffusion in the supported lipid bilayer.
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