2010 Fiscal Year Final Research Report
Genetic anthropology of the blood lipid level
| Project/Area Number |
21687021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical anthropology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
NAKAYAMA Kazuhiro Jichi Medical University, 医学部, 助教 (90433581)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 遺伝子 / 多型 / 人類 / 進化 / 中性脂肪 / コレステロール |
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| Research Abstract |
To elucidate anthropological significance of genetic variation for blood lipid level in humans, over 20,000 individuals from 5 Asian and Oceanian groups were investigated for common and rare variants of lipid associated genes. 1) Effects of FADS (fatty acid desaturase) gene variants on blood lipid level were dramatically varied between Mongolians and Japanese. Differences in dietary intake of unsaturated fatty acid would explain the variation in phenotypic effects of the FADS gene variants. 2) Anti-hypertriglyceridemic MLXIPL Gln241His variant was found with high frequencies in central Asians who can be traced back to nomadic pastoralists. Gln241His variant might have been significant for utilization of carbohydrates and fats in nomadic pastoralists. 3) Resequencing of Scavenger receptor class B gene family revealed excess of rare variants among Thai individuals. This suggested a possible link between genetic variation of lipid metabolism and malaria resistance. 4) Additionally, the present study showed that in an association study of blood lipid level, adjustment for visceral fat accumulation can improve sensitivity of detecting effects of genetic variants.
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[Journal Article] Jichi Medical University Promotion Team of a Large-scale Human Genome Bank for All over Japan A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.2010
Author(s)
Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, Ogawa A, Munkhtulga L, Chimedregze U, Kagawa Y, Ishibashi S, Iwamoto S
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Journal Title
Human Genetics. 127
Pages: 685-690
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[Journal Article] Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI.2010
Author(s)
Munkhtulga L, Nagashima S, Nakayama K, Utsumi N, Yanagisawa Y, Gotoh T, Omi T, Kumada M, Zolzaya K, Lkhagvasuren T, Kagawa Y, Fujiwara H, Hosoya Y, Hyodo M, Horie H, Kojima M, Ishibashi S, Iwamoto S
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Journal Title
Obesity (Silver Spring). 18
Pages: 1006-1014
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[Journal Article] Jichi Community Genetics Team (JCOG) Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.2009
Author(s)
Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, Yanagisawa Y, Okayama M, Kajii E, Ishibashi S, Iwamoto S
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Journal Title
Journal of Medical Genetics 46
Pages: 370-374
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