2011 Fiscal Year Final Research Report
Molecular basis of cholesterol efflux by ABCG1
| Project/Area Number |
21688007
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | ABCタンパク質 / 脂質 / コレステロール / 動脈硬化 / アルツハイマー病 |
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| Research Abstract |
It was demonstrated that ABCG_1 and ABCG_4 , a lipid transporter, suppress amyloidβsecretion and that ABCG_1 stimulates axonal extension of central nervous neurons. Analysis of purified proteins suggested that ABCG_1 transports cholesterol and choline phospholipid, while ABCG_4 transports cholesterol. It was also demonstrated that ABCG_1 and ABCG_4 distribute to distinct domains on the plasma membrane and transport lipid by modulating the domain structures.
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Author(s)
Ishigami, M., Tominaga, Y., Nagao, K., Kimura, Y., Matsuo, M., Kioka, N., and Ueda, K
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Journal Title
Biochim. Biophys. Acta
Volume: 1831
Pages: 683-690
DOI
Peer Reviewed
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[Journal Article] ATP hydrolysis-dependent conformational change in the extracellular domain of ABCA1 are associated with apoA-I binding.2012
Author(s)
Nagao, K., Takahashi, K., Azuma, Y., Takada, M., Kimura, Y., Matsuo, M., Kioka, N., and Ueda, K.
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Journal Title
J. Lipid Res
Volume: 53
Pages: 126-136
DOI
Peer Reviewed
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[Journal Article] Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells2012
Author(s)
Sezaki, T., Inada, K., Sogabe, T., Kakuda, K., Tomiyama, L., Matsuno, Y., Ichikawa, T., Matsuo, M., Ueda, K.,and Kioka N.
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Journal Title
DOI
Peer Reviewed
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