2011 Fiscal Year Final Research Report
Molecular mechanisms for neurogenesis and psychiatric dysfunction in postnatal and adult periods
| Project/Area Number |
21689013
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
ENOMOTO Atsushi 名古屋大学, 大学院・医学系研究科, 特任准教授 (20432255)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子 / 発生医学 |
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| Research Abstract |
We showed that the actin-binding protein Girdin binds to DISC1, a susceptibility gene for schizophrenia, and regulates the migration and positioning of newborn neurons in the dentate gyrus of the hippocampus during postnatal and adult periods. Furthermore, we identified that Girdin is crucial for the migration of neuroblasts born in the subventricular zone. We also studied the function of two members of the Girdin family of proteins, Gipie and Daple, and found that they regulate the ER stress response and the Wnt signaling pathway, respectively.
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