2010 Fiscal Year Final Research Report
Structural studies on influenza viral RNA polymerase for designing new anti-viral drug
| Project/Area Number |
21689014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Yokohama City University |
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Principal Investigator |
OBAYAHI Eiji Yokohama City University, 大学院・生命ナノシステム科学研究科, 特任助教 (50321740)
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| Project Period (FY) |
2009 – 2010
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| Keywords | インフルエンザ / RNAポリメラーゼ / 構造解析 |
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| Research Abstract |
As one of the measures to the menace of the new influenza virus appearance, I performed structural studies for designing new anti-influenza viral drug. Because a compound which can inhibit the function of viral RNA polymerase playing a central role in the replication of the influenza virus will be a good candidate, I solved a crystal structure of the RNA polymerase. In addition, using purified RNA polymerase in this study, I succeeded in the making of the antibody which suppressed a function of RNA polymerase. Drug development based on these results is expected in future.
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