A new therapeutic strategy for tumor induced bone destruction targeting FAK

2011 Fiscal Year Final Research Report

• Project/Area Number: 21689050
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: SHIMO Tsuyoshi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40362991)
• Project Period (FY): 2009 – 2011
• Keywords: FAK / 破骨細胞 / 癌骨浸潤

Research Abstract

Focal adhesion kinase(FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions. FAK overexpression is frequently found in invasive and metastatic cancers, but its role in osteolytic metastasis is not well understood. In this study, we have analyzed anti-tumor effects of the FAK against bone metastasis in cancer, we found that FAK was critically involved in osteolytic metastasis and activated in tumors, pre-osteoclasts, and mature osteoclasts. These results suggest that FAK can be effective target for the treatment of cancer induced bone metastasis.

Research Products

• [Journal Article] Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma (2012)
  • Author(s): Naito Kurio, Tsuyoshi Shimo, Takuya Fukazawa, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tatsuki Honami, Yuu Horikiri, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • Journal Title: Oral Oncology Volume: (accepted)
  • Peer Reviewed
• [Journal Article] Effect of a novel FAK inhibitor TAE226 on the breast cancer associated with bone metastasis (2011)
  • Author(s): Naito Kurio, Tsuyoshi Shimo, Takuya Fukazawa, Munenori Takaoka, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tatsuki Honami, Shinji Hatakeyama, Masahiko Ikeda, Yoshio Naomoto, Akira Sasaki
  • Journal Title: Experimental Cell Research Volume: 317(8) Pages: 1134-1146
  • Peer Reviewed
• [Journal Article] Mechanism of cancer-induced bone destruction : An association of connective tissue growth factor(CTGF/CCN2) in the bone metastasis (2011)
  • Author(s): Tsuyoshi Shimo, Akira Sasaki
  • Journal Title: Jap Dental Science Review Volume: 47(1) Pages: 13-22
  • Peer Reviewed
• [Journal Article] Sonic Hedgehog Signaling Promotes Growth of Oral Squamous Cell Carcinoma Cells Associated with Bone Destruction (2011)
  • Author(s): Tatsuki Honami, Tsuyoshi Shimo, Tatsuo Okui, Naito Kurio, Nur Mohammad Monsur Hassan, Masahiro Iwamoto, Akira Sasaki
  • Journal Title: Oral Oncology Volume: 48(1) Pages: 49-55
  • Peer Reviewed
• [Journal Article] Induction of MMP-13 Expression in Bone-metastasizing Cancer Cells by Type I Collagen through Integrinα1β1 andα2β1-p38 MAPK Signaling (2011)
  • Author(s): Soichiro Ibaragi, Tsuyoshi Shimo, Masahiro Iwamoto, Nur Mohammad Monsur Hassan, Sachiko Isowa, Naito Kurio, Hiroki Mandai, Shinichi Kodama, Akira Sasaki.
  • Journal Title: Anticancer Research Volume: 31(4) Pages: 1307-1314
  • Peer Reviewed
• [Journal Article] Anti-tumor Effect of Temsirolimus against Oral Squamous Cell Carcinoma Associated with Bone Destruction (2010)
  • Author(s): Tatsuo Okui, Tsuyoshi Shimo, Takuya Fukazawa, Naito Kurio, Nur Mohammad Monsur Hassan, Tatsuki Honami, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • Journal Title: Molecular Cancer Therapeutics Volume: 9(11)
  • Peer Reviewed
• [Journal Article] PTHrP regulates angiogenesis and bone resorption via VEGF expression (2010)
  • Author(s): Sachiko Isowa, Tsuyoshi Shimo, Soichiro Ibaragi, Naito Kurio, Tatsuo Okui, Kiminori Matsubara, Nur Mohammad Monsur Hassan, Koji Kishimoto, Akira Sasaki.
  • Journal Title: Anticancer Research Volume: 30(7) Pages: 2755-2767
  • Peer Reviewed
• [Journal Article] Bone destruction by invading oral squamous carcinoma cells mediated by the transforming growth factor-βsignaling pathway (2010)
  • Author(s): Takeshi Goda, Tsuyoshi Shimo, Yasuto Yoshihama, Nur Mohammad Monsur Hassan, Soichiro Ibaragi, Naito Kurio, Tatsuo Okui, Tatsuki Honami, Koji Kishimoto, Akira Sasaki
  • Journal Title: Anticancer Research Volume: 30(7) Pages: 2615-2623
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells (2010)
  • Author(s): Soichiro Ibaragi, Tsuyoshi Shimo, Masahiro Iwamoto, Nur Mohammad Monsur Hassan, Shinichi Kodama, Sachiko Isowa, and Akira Sasaki
  • Journal Title: Anticancer Research Volume: 30(12) Pages: 5029-5036
  • Peer Reviewed
• [Presentation] Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma (2012)
  • Author(s): Naito Kurio, Tsuyoshi Shimo, Nur Mohammad Monsur Hassan, Tatsuo Okui, Tatsuki Honami, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • Organizer: The 5th International Symposium for Future Technology Creating Better Human Health and Society
  • Place of Presentation: Okayama
  • Year and Date: 20120315-16
• [Presentation] A Novel Focal Adhesion Kinase Inhibitor TAE226 Suppresses Parathyroid Related Protein Induced Hypercalcemia and Reduced Osteoclast Activation (2010)
  • Author(s): Naito Kurio, Tsuyoshi Shimo, Nur Mohammad Monsur Hassan, Tatsuo Okui, Tatsuki Honami, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
  • Organizer: The 3rd International Symposium for Future Technology Creating Better Human Health and Society
  • Place of Presentation: Okayama
  • Year and Date: 20100203-04
• [Presentation] Inhibition of Focal Adhesion Kinase Suppresses Breast Cancer Induced Bone Metastasis (2009)
  • Author(s): Naito Kurio, Tsuyoshi Shimo, Munenori Takaoka, Tatsuo Okui, Norie Yoshioka, Nur Mohammad Monsur Hassan, Shinji Hatakeyama, Yoshio Naomoto, Akira Sasaki
  • Organizer: The American Society for Bone and Mineral Research 31st Annual Meeting
  • Place of Presentation: Colorado, USA
  • Year and Date: 20090911-15
• [Book] Squamous Cell Carcinoma : Role of connective tissue growth factor(CTGF/CCN2) in oral squamous cell carcinoma-induced bone destruction (2012)
  • Author(s): Tsuyoshi Shimo, Akira Sasaki
  • Total Pages: 175-194
  • Publisher: InTech