2011 Fiscal Year Final Research Report
Identification of stem cell niche in periodontal skeleton and its molecular regulatory mechanisms.
| Project/Area Number |
21689051
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ONO Noriaki 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (20451908)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 幹細胞 / 幹細胞ニッチ / 歯周組織 / 歯根形成 / 内軟骨性骨化 / 傍軟骨膜 / 血管内皮 / 微小血管 |
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| Research Abstract |
How putative stem-like cells residing in the periodontal and craniofacial skeleton are generated has been incompletely understood. Compound transgenic mice harboring an inducible Cre recombinase and a fluorescent reporter were used for the purpose of lineage-tracing experiments. The preliminary data suggest that early cells involving skeletogenesis are highly heterogeneous and comprised of a wide spectrum of cells including endothelial cells. In addition, each subset of progenitors is destined for different fate and functionality during development and regeneration.
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Research Products
(5 results)
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[Journal Article] Constitutively active PTH/PTHRP receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation2012
Author(s)
Ono, N., Nakashima, K., Schipani, E., Hayata, T., Ezura, Y., Soma, K., Kronenberg, H. M., Noda, M.
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Journal Title
Journal of Cellular Physiology
Volume: 227(2)
Pages: 408-15
Peer Reviewed
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[Journal Article] A Novel Population of Cells Expressing Both Hematopoietic and Mesenchymal Markers Is Present in the Normal Adult Bone Marrow and Is Augmented in a Murine Model of Marrow Fibrosis2012
Author(s)
Ohishi M, Ono W, Ono N, Khatri R, Marzia M, Baker EK, Root SH, Wilson TL, Iwamoto Y, Kronenberg HM, Aguila HL, Purton LE, Schipani E.
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Journal Title
American Journal of Pathology
Volume: 180(2)
Pages: 811-8
Peer Reviewed
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[Journal Article] Osteopontin deficiency enhances parathyroid hormone/parathyroid hormone related peptide receptor(PPR) signaling-induced alteration in toothformation and odontoblastic morphology2011
Author(s)
Morishita, M., Ono, N., Miyai, K., Nakagawa, T., Hanyu, R., Nagao, M., Kamolratanakul, P., Notomi, T., Rittling, S. R., Denhardt, D. T., Kronenberg, H. M., Ezura, Y., Hayata, T., Nakamoto, T., Noda, M.
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Journal Title
Tissue & Cell
Volume: 43(3)
Pages: 196-200
Peer Reviewed
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