2011 Fiscal Year Final Research Report
Regulation, maintenance, and plasticity of central dopaminergic synapses
| Project/Area Number |
21700347
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
TOKUOKA Hirofumi 東京工業大学, 大学院・生命理工学研究科, 助教 (10452020)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ドーパミン / 黒質 / 線条体 / 大脳基底核 / チロシン水酸化酵素 / 遺伝子ノックアウトマウス |
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| Research Abstract |
The tyrosine hydroxylase(TH) gene, essential for dopamine synthesis, is partially ablated in adult nigrostriatal projection. TH reduction in axon terminals is slower than in soma, and dopamine is better maintained than TH. Our data suggest striatal dopamine is compensatorily regulated by axonal TH level and L-DOPA synthesis activity per TH level. This regulation has potential relevance to pathogenesis of Parkinson disease and other dopamine-related psychiatric disorders.
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