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2010 Fiscal Year Final Research Report

Search for an aberrant splicing associated with schizophrenia specific antigen

Research Project

  • PDF
Project/Area Number 21700385
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionFujita Health University

Principal Investigator

MANABE Takayuki  Fujita Health University, 総合医科学研究所, 講師 (90382283)

Project Period (FY) 2009 – 2010
Keywords統合失調症 / リンパ芽球 / スクリーニング
Research Abstract

This research topic has aimed the comparative study of the difference of the production style of antibodies between the normal and the schizophrenia patients using the lymphoblastoid cell lines obtained from both groups. By this research topic, it has been demonstrated that the selectivity of J1-3 and J7 are different from the normal control in schizophrenia.

  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Altering the expression balance of hnRNP C1 and C2 changes the expression of myelination-ewlated genes.2011

    • Author(s)
      Iwata K., Matsuzaki H., Manabe T., Mori N.
    • Journal Title

      Psychiat.Res. in press

    • Peer Reviewed
  • [Journal Article] Aberrant regulation of alternative splicing in Schizophrenia.2010

    • Author(s)
      Morikawa T., Manabe T.
    • Journal Title

      Neurochem.Int. 57

      Pages: 691-704

    • Peer Reviewed
  • [Journal Article] Animal models of autism : an epigenetic and environmental viewpoint.2010

    • Author(s)
      Iwata K., Matsuzaki H., Takei N., Manabe T., Mori N.
    • Journal Title

      Journal of Central Nervous System Disease 2

      Pages: 37-44

    • Peer Reviewed
  • [Journal Article] The expression of HMGA1a is increased in lymphoblastoid cell lines from Schizophrenia patients.2010

    • Author(s)
      Morikawa T., Manabe T., Ito Y., Yamada S., Yoshimi A., Nagai T., Ozaki N., Mayeda A.
    • Journal Title

      Neurochem.Int. 56

      Pages: 736-739

    • Peer Reviewed
  • [Journal Article] Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells using RNAi Against Transcription Factor L3/Lhx8.2010

    • Author(s)
      Manabe T., Wanaka A.
    • Journal Title

      Methods Mol.Biol. 650

      Pages: 101-109

  • [Journal Article] Transient activation of Notch signaling in the injured adult brain.2010

    • Author(s)
      Tatsumi K., Okuda H., Makinodan M., Yamauchi T., Makinodan E., Matsuyoshi H., Manabe T., Wanaka A.
    • Journal Title

      J.Chem.Neuroanat. 39

      Pages: 15-19

    • Peer Reviewed
  • [Journal Article] The HMGA1a recognition candidate DNA sequencesin human.2009

    • Author(s)
      Manabe T., Katayama T., Tohyama M.
    • Journal Title

      PLoS One 4

      Pages: e8004

    • Peer Reviewed
  • [Journal Article] Oncogenic HMGA1a protein causes Sporadic Alzheimer's disease-associated aberrant splicing : The molecular mechanism reveals a link with U1 snRNP-mediated gene repression system.2009

    • Author(s)
      Mayeda A., Manabe T., Ohe K.
    • Journal Title

      Protein, Nucleic Acid, Enzyme. 54

      Pages: 2245-2250

  • [Presentation] 統合失調症患者で転写・スプライシング調節因子であるHMGA1aが上昇している意義2010

    • Author(s)
      眞部孝幸、森川智美、山下祐子、前田明
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] 統合失調症患者におけるhnRNP A1 による異常スプライシング2009

    • Author(s)
      眞部孝幸、前田明
    • Organizer
      第32回分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
  • [Presentation] 統合失調症と異常スプライシング2009

    • Author(s)
      眞部孝幸、前田明
    • Organizer
      第69回日本解剖学会中部支部大会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-10
  • [Presentation] 腸管神経堤細胞の移動様式2009

    • Author(s)
      榎本秀樹、西山千尋、眞部考幸、Heather Young、Don Newgreen.
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
  • [Presentation] 統合失調症の異常スプライシングにグローバルなスプライシング抑制因子であるhnRNP A1が関与している可能性を探る2009

    • Author(s)
      眞部孝幸、前田明
    • Organizer
      第11回日本RNA学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-07-28

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Published: 2012-02-13   Modified: 2016-04-21  

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