2010 Fiscal Year Final Research Report
Analysis of PKC-dependent amyloid-beta reduction mechanism by alpha-secretase complex
| Project/Area Number |
21700396
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Juntendo University |
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Principal Investigator |
KASHIYAMA Taku Juntendo University, 医学部, 助教 (90338343)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経変性疾患 / アミロイドベータ |
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| Research Abstract |
Amyloid-beta (Ass), which plays a major role in Alzheimer disease, is generated by ss and _Y cleavage of Amyloid precursor protein (APP). While ss cleavage, which occur within A_Y, competitively reduces Ass production. Therefore, acceleration of α cleavage may be one of the therapeutic strategies for Alzheimer disease. To determine a cleavage mechanism specific for APP, we developed a tool for analyzing cleavage mechanism in other substrates, which is also cleaved by α-and ss-secretase.
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