2010 Fiscal Year Final Research Report
Functional analysis of EMAP-II, a cytokine released during cell death, in the neurogenesis.
| Project/Area Number |
21700402
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
IGUCHI Tokuichi University of Fukui, 医学部, 特命助教 (60509305)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 神経科学 / 細胞・組織 / シグナル伝達 / サイトカイン |
|---|
| Research Abstract |
It is known that neurogenesis happens at the region of the injuries such as the stroke, and the elucidation of the mechanism leading from the death to the regeneration of the cell has high therapeutic implications. We found that EMAP-II, a molecule secreted owing to cell death, was increased in peripheral blood vessels during a stroke. Furthermore, EMAP-II acted on neural stem cells to induce the expression of FILIP1L which participats in proliferation and differentiation of a cell. Both of them were highly expressed in the olfactory bulb where the neurogenesis occurs actively. These results suggested a part of the mechanism linking cell death and neurogenesis.
|
