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2010 Fiscal Year Final Research Report

Establishment of the rabbit pluripotent stem cell systems for compensating for the difference between human and mouse stem cells.

Research Project

  • PDF
Project/Area Number 21700453
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

HONDA Arata  The Institute of Physical and Chemical Research, 遺伝工学基盤技術室, 客員研究員 (10373367)

Project Period (FY) 2009 – 2010
Keywordsウサギ / 多能性幹細胞 / ES細胞 / iPS細胞
Research Abstract

I identified that bFGF can maintain the undifferentiated status of rabbit ES cells and found that Activin signaling through Smad2/3 activation is necessary to maintain the pluripotent status of rabbit ES cells as those of human ES cells. Moreover, I successfully generated rabbit induced pluripotent stem cells.

  • Research Products

    (10 results)

All 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Generation of induced pluripotent stem cells in rabbits : potential experimental models for human regenerative medicine.2010

    • Author(s)
      Honda A, Hirose M, Hatori M, Matoba A, Miyoshi H, Inoue K, Ogura A.
    • Journal Title

      J.Biol.Chem. (in press.)

    • Peer Reviewed
  • [Journal Article] ウサギ多能性幹細胞とその可能性2010

    • Author(s)
      本多新
    • Journal Title

      アニテックス 22

      Pages: 26-31

  • [Journal Article] Basic FGF and Activin/Nodal but not LIF signaling sustain undifferentiated status of rabbit embryonic stem cells.2009

    • Author(s)
      Honda A, Hirose M, Ogura A.
    • Journal Title

      Exp.CellRes. 315

      Pages: 2033-2042

    • Peer Reviewed
  • [Presentation] Generation of induced pluripotent stem cells in rabbits.2010

    • Author(s)
      Honda A, Hirose M, Hatori M, Matoba A, Miyoshi H, Inoue K, Ogura A.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      20101207-20101210
  • [Presentation] ウサギ多能性幹細胞の樹立とその解析2010

    • Author(s)
      本多新
    • Organizer
      第四回ウサギフォーラム
    • Place of Presentation
      秋田
    • Year and Date
      2010-07-24
  • [Presentation] ウサギ多能性幹細胞とその可能性2010

    • Author(s)
      本多新
    • Organizer
      第36回重粒子医科学センター研究交流会
    • Place of Presentation
      千葉
    • Year and Date
      2010-05-13
  • [Presentation] ウサギES細胞の樹立・維持に影響を及ぼす因子とシグナル伝達経路の解析2009

    • Author(s)
      本多新、廣瀬美智子、小倉淳郎
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-20091212
  • [Presentation] ウサギES細胞の樹立と未分化生維持機構の解析2009

    • Author(s)
      廣瀬美智子、本多新、小倉淳郎
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      さいたま
    • Year and Date
      20090514-20090516
  • [Presentation] Current status of rabbit ES cells : where are we and where can we go?2009

    • Author(s)
      Honda A.
    • Organizer
      The Third International Meeting on Rabbit Biotechnology.
    • Place of Presentation
      中国(西安)
    • Year and Date
      2009-06-24
  • [Remarks] ホームページ等

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Published: 2012-02-13   Modified: 2016-04-21  

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