2010 Fiscal Year Final Research Report
Establishment of the rabbit pluripotent stem cell systems for compensating for the difference between human and mouse stem cells.
| Project/Area Number |
21700453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HONDA Arata The Institute of Physical and Chemical Research, 遺伝工学基盤技術室, 客員研究員 (10373367)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ウサギ / 多能性幹細胞 / ES細胞 / iPS細胞 |
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| Research Abstract |
I identified that bFGF can maintain the undifferentiated status of rabbit ES cells and found that Activin signaling through Smad2/3 activation is necessary to maintain the pluripotent status of rabbit ES cells as those of human ES cells. Moreover, I successfully generated rabbit induced pluripotent stem cells.
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