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2010 Fiscal Year Final Research Report

Effects of localized compliance on gas dispersion in small airways

Research Project

  • PDF
Project/Area Number 21700478
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

SERA Toshihiro  The Institute of Physical and Chemical Research, 階層統合シミュレーション研究協力グループ, 研究員 (40373526)

Project Period (FY) 2009 – 2010
Keywords末梢気道 / ガス拡散 / 数値計算 / 放射光
Research Abstract

During respiration, airflow is induced by lung deformation, and so gas exchange and mass transport is performed. In this study, to understand the respiratory physiology in deep lung, we observed and analyzed small airway deformation using synchrotron radiation-CT and simulated alveolar flow numerically. As the results, the airway deformation was larger in smaller airways, and the diameter increased by about 100% compared with the values at functional residual capacity. And, the morphometric change was lower of only asthmatic small airways. In numerical simulation of gas dispersion, it was promoted by airway deformation.

  • Research Products

    (7 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] 気道末梢部位のイメージングと気流解析2009

    • Author(s)
      世良俊博、横田秀夫、上杉健太朗、八木直人
    • Journal Title

      可視化情報学会誌 29(114)

      Pages: 191-196

    • Peer Reviewed
  • [Journal Article] 小動物用高分解能in vivo-CTシステムの開発-生きた小動物の心臓や肺の動きを捉える-2009

    • Author(s)
      世良俊博
    • Journal Title

      光アライアンス 20(5)

      Pages: 27-31

  • [Presentation] 放射光CTを用いた肺胞の動態観察2011

    • Author(s)
      世良俊博
    • Organizer
      理研シンポジウム(生体力学シミュレーション)
    • Place of Presentation
      埼玉
    • Year and Date
      2011-03-09
  • [Presentation] 肺胞の動態観察と気流シミュレーション2011

    • Author(s)
      世良俊博
    • Organizer
      バイオフィジオロジー研究会
    • Place of Presentation
      京都
    • Year and Date
      2011-02-25
  • [Presentation] The relationship between alveoli and alveolar ducts in lung inflation2010

    • Author(s)
      Toshihiro SERA
    • Organizer
      World Congress of Biomechanics
    • Place of Presentation
      Singapore
    • Year and Date
      2010-08-01
  • [Presentation] 放放射光を用いた気道末梢部位の動態観察2010

    • Author(s)
      世良俊博
    • Organizer
      理研シンポジウム(生体力学シミュレーション)
    • Place of Presentation
      埼玉
    • Year and Date
      2010-03-09
  • [Presentation] Gas dispersion in multiple branching small airways induced by rhythmical breathing motion.2009

    • Author(s)
      Toshihiro SERA
    • Place of Presentation
      Oxford
    • Year and Date
      2009-09-24

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Published: 2012-02-13   Modified: 2016-04-21  

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