2010 Fiscal Year Final Research Report
Effects and mechanisms of the combination of exercise training and AGE inhibitor.
| Project/Area Number |
21700522
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
GUO Qi Tohoku University, 大学院・医学系研究科, 非常勤講師 (50509544)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 運動 / インスリン抵抗性 / 骨格筋 / 腎不全 / アンジオテンシンII受容体拮抗薬 / AGEs / Methylglyoxal |
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| Research Abstract |
Advanced glycation endproducts (AGEs) plays a pivotal role in the development of diabetes, hypertension and renal injury. Our results have demonstrated that exercise training or AGE inhibitor have effects on the hypertension, insulin resistance and renal injury, furthermore, additive effects of exercise training to AGE inhibitor were shown. The mechanisms of these effects could have involved in the rennin angiotensin system, oxidative stress, and skeletal muscle capillary network.
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[Journal Article] Methylglyoxal Contributes to the Development of Insulin Resistance and Salt Sensitivity in Sprague Dawley Rats.2009
Author(s)
Qi Guo, Takefumi Mori, Yue Jiang, Chunyan Hu, Yusuke Osaki, Yoshimi Yoneki, Ying Sun, Takuma Hosoya, Akihiro Kawamata, Susumu Ogawa, Masaaki Nakayama, Toshio Miyata, Sadayoshi Ito.
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Journal Title
J Hypertens. 27(8)
Pages: 1664-1671
Peer Reviewed
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[Presentation] Effects of losartan and thiazide diuretic on insulin resistance and muscular circulation in fructose-fed rats.2010
Author(s)
Qi Guo, Takefumi Mori, Chunyan Hu, Yue Jiang, Yusuke Osaki, Yoshimi Yoneki, Takashi Nakamichi, Takuma Hosoya, Hiroshi Sato, Sadayoshi Ito.
Organizer
The 12th Asian Pacific Congress of Nephrology
Place of Presentation
Seoul, Korea
Year and Date
20100605-20100608
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