2010 Fiscal Year Final Research Report
Clarification of molecular mechanism in prevention of muscular atrophy by transient blood flow restriction.
| Project/Area Number |
21700548
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Juntendo University |
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Principal Investigator |
KAKEHI Saori Juntendo University, 医学部, 研究員 (00450560)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 筋萎縮 |
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| Research Abstract |
Transient blood flow restriction prevents muscular atrophy and weakness induced by chronic unloading. However, it was unclear which molecular mechanism. In cultured C2C12 myotube, the mRNA level of ubiquitin ligase atrogin-1・MuRF1 and the decreasing of diameter were inhibited by hypoxic stimulation at hydrogen peroxide -induced muscle atrophy model. On the other hand, the amount of insulin stimulated glucose uptake was decreased by 24 hours hind limb fixation.
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[Journal Article] Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men.
Author(s)
Sakurai Y, Tamura Y, Takeno K, Kumashiro N, Sato F, Kakehi S, Ikeda S, Katamoto S, Ogura Y, Saga N, Naito H, Fujitani Y, Hirose T, Kawamori R, Watada H
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Journal Title
J Diabetes Invest. in press
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