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2010 Fiscal Year Final Research Report

A multifaceted approach to elucidate the associations of genetic polymorphisms and lifestyle factors with autonomic nervous system function.

Research Project

  • PDF
Project/Area Number 21700691
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionKyoto University

Principal Investigator

MATSUNAGA Tetsuro  Kyoto University, 農学研究科, 研究員 (10452286)

Project Period (FY) 2009 – 2010
Keywords遺伝子多型 / 自律神経 / 心拍変動 / 胃運動 / 胃電図 / 食習慣 / 栄養 / 生活習慣病
Research Abstract

Hypoactivity of autonomic nervous system (ANS) is closely associated with pathogenesis and progress of cardiovascular or metabolic diseases. Both genetic and environmental factors are intricately related to the hypofunction of ANS. Therefore, multifaceted analyses of these factors can contribute to establishment of the personalized medicine or nutrition. Present study showed that the genetic polymorphisms of leptin, leptin receptor, ghrelin, and growth hormone secretagogue receptor are significantly associated with differences in ANS activity, energy intake, gastric motility, blood pressure, or body weight. These observations suggest that studied polymorphisms may be potential risk of related diseases.

  • Research Products

    (4 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Association of estrogen receptor-alpha polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males.2010

    • Author(s)
      Tetsuro Matsunaga, Ning Gu, Hanae Yamazaki, Tetsuya Adachi, Koichiro Yasuda, Toshio Moritani, Kinsuke Tsuda, Tohru Nishiyama, Masahiko Nonaka
    • Journal Title

      Clinica Chimica Acta 411

      Pages: 505-509

    • Peer Reviewed
  • [Presentation] レプチンおよびレプチン受容体における遺伝子多型と自律神経活動2010

    • Author(s)
      松永哲郎
    • Organizer
      胃運動機能との関連解析第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-22
  • [Presentation] レプチンおよびレプチン受容体遺伝子多型とエネルギー摂取量2010

    • Author(s)
      松永哲郎
    • Organizer
      自律神経機能との関連解析第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-01-09
  • [Presentation] グレリンLeu72Met多型とエネルギー摂取量2009

    • Author(s)
      松永哲郎
    • Organizer
      胃運動機能、自律神経機能との関連解析第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22

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Published: 2012-02-13   Modified: 2016-04-21  

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