2011 Fiscal Year Final Research Report
The physiological activities of lignophenol on the risk-factors of arteriosclerosis
| Project/Area Number |
21700740
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 食素材 |
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| Research Abstract |
Adipose tissue is not simply a store of excess energy, but also secretes a variety of hormones called adipocytokines, which are adipose-specific secretory factors. Dysregulated secretion of adipocytokines participates in the pathogenesis of lifestyle-related diseases such as diabetes, hyperlipaemia, hypertension. Accumulation of excess visceral fat caused dysregulated production of adipocytokines. Therefore, regulation of adipocytokines and fat metabolism are important to prevent lifestyle-related diseases.
Lignin is one of the components in the plant cell wall, after cellulose, making up 20-30% of the global plant biomass. Lignophenols are derivatives of lignin, which possess high phenolic function and antioxidant properties. However, their medicinal property is not well characterized.
In this study, our major findings were as follows :(i) lignophenols decreased oleate-induced hyperlipidemia model in human hepatocellular cells,(ii) lignophenols decreased the mRNA expression of adipocytokine which induced lifestyle-related diseases in mouse adipose cells.
The current research outcome would be useful for investigating a potential strategy for the prevention of lifestyle-related diseases through the regulation of lipid and adipocytokine metabolisms.
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Research Products
(3 results)
