2010 Fiscal Year Final Research Report
Investigation of pre-biomarker for social stress-inducible obesity in mice
| Project/Area Number |
21700761
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
SAKAKIBARA Hiroyuki University of Shizuoka, 環境科学研究所, 助教 (20403701)
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| Research Collaborator |
SHIMOI Kayoko 静岡県立大学, 環境科学研究所, 教授 (10162728)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 健康と食生活 / ストレス性肥満 / 食品由来因子 / プレバイオマーカー |
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| Research Abstract |
Mice were singly housed with reduced bed-volume for 3 months. Their body and visceral fat weights were significantly increased in combination with hepatic hypertrophy because of lipid deposition comparing to the control (5 mice/cage). The alterations of blood creatine kinase and plasminogen activator inhibitor type 1 (PAI-1) levels were suggested to might be used as pre-biomarker for social stress-inducible obesity. Additionally, PAI-1 increased under stressful events might not affect on sleep disturbance.
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[Presentation] Absorption and encretion of bilberry anthocyanins in mice2009
Author(s)
Sakakibara H., Ogawa T., Ogawa., K., Koyanagi A., Kobayashi S., Goda T., Kumazawa S., Kobayashi H., Shimoi K.
Organizer
4th International Conference on Polyphenols and Health
Place of Presentation
Harrogate International Center, Harrogate, UK
Year and Date
20091207-20091211
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[Presentation] Loss of social interaction induces obesity in mice2009
Author(s)
Sakakibara H., Suzuki A., Kobayashi A.,Matsui A., Koyanagi A., Sayama K., Koto A., Ohashi N., Akimoto M.,Nakayama T., Shimoi K
Organizer
The 2nd International Conference on Health and Longevity Sciences
Place of Presentation
Shizuoka, Japan.
Year and Date
20091024-20091027
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