2010 Fiscal Year Final Research Report
Investigation on toxic effects of organophosphate pesticide to endocrine organs related to reproductive system, and identification of target molecules of the chemicals in these organs.
| Project/Area Number |
21710069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Saitama Medical University |
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Principal Investigator |
HIROSAWA Narumi Saitama Medical University, 医学部, 助教 (40327060)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 有機リン系農薬 / 生殖毒性 / プロテオーム |
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| Research Abstract |
I carried out exposure experiments to the mature male rats in order to investigate the effects of the fenitrothion on endocrine organs. As the result, in the 30 mg/kg/day administrated group, adrenal and pituitary glands showed the increase in the weight. In addition, testosterone and ACTH blood concentration were increased by the administration of fenitrothion. I quantitatively compared the expressed proteins on the each glands of administrated with control groups and performed identifications of the interest proteins based on the proteomic method.
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[Journal Article] Bisphenol A in combination with TNF-alpha selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity.2010
Author(s)
Guo H, Liu T, Uemura Y, Jiao S, Wang D, Lin Z, Narita Y, Suzuki M, Hirosawa N, Ichihara Y, Ishihara O, Kikuchi H, Sakamoto Y, Senju S, Zhang Q, Ling F.
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Journal Title
Cell Mol Immunol. 7(3)
Pages: 227-234
Peer Reviewed
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[Journal Article] Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells.2009
Author(s)
Uemura Y, Liu TY, Narita Y, Suzuki M, Nakatsuka R, Araki T, Matsumoto M, Iwai LK, Hirosawa N, Matsuoka Y, Murakami M, Kimura T, Hase M, Kohno H, Sasaki Y, Ichihara Y, Ishihara O, Kikuchi H, Sakamoto Y, Jiao SC, Senju S, Sonoda Y.
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Journal Title
J Immunol. 183(1)
Pages: 201-208
Peer Reviewed
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