2010 Fiscal Year Final Research Report
Identification and characterization of unique radical SAM enzymes, which use S-adenosyl methionine as oxidant
| Project/Area Number |
21710224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KUDO Fumitaka Tokyo Institute of Technology, 大学院・理工学研究科, 准教授 (00361783)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生合成 / 酵素化学 / ラジカルSAM酵素 / 二次代謝遺伝子 / 放線菌 / ネオマイシン / ゲンタミシン / カルバペネム抗生物質 |
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| Research Abstract |
Identification of new radical SAM enzyme gene was found to be an efficient strategy to identify novel secondary metabolic biosynthetic gene cluster. Further, a novel radical SAM epimerase involved in neomycin biosynthesis was characterized.
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