2011 Fiscal Year Final Research Report
Development of carbohydrate probes toward medicinal applications
| Project/Area Number |
21710230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Wakayama University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生理活性分子の設計・合成 / 糖鎖合成 |
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| Research Abstract |
Organic synthesis of three type (N-acetyl, de-N-acetyl and lactamized) sialyl(2-6)gal 6 sulfo LacNAc probes for the biochemical experiments to investigate the mechanism of neo-immunologic function, were achieved. In the proteoglycan carbohydrate chain, developed a new method for the introduction of intact ChS and oligosaccharides into the peptide. Then, clarified the introduction of GAG saccharide would improvethe biopharmaceutical properties of drugs.The construction of GAG oligosaccharides were achievedutilized the developed hybrid type synthetic method which correspondto the glycosaminoglycan oligosaccharides synthesis. The construction of tumor associate carbohydrate antigen were partly achievedutilized the developed hybrid type synthetic method which correspondto the sialo carbohydrate synthesis.
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