2010 Fiscal Year Final Research Report
Study of picosecond-timescale fluctuation of water molecules around proteins
| Project/Area Number |
21740313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
YAMAGUCHI Mariko Nara Institute of Science and Technology, 物質創成科学研究科, 助教 (50521738)
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| Project Period (FY) |
2009 – 2010
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| Keywords | テラヘルツ / タンパク質 / 水和 |
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| Research Abstract |
Water is important for proteins because it stabilizes protein structure and also makes proteins active. Water fluctuation needs to be clarified in order to understand the mechanisms of protein function. In this work water fluctuation around proteins has been studied by using terahertz time-domain spectroscopy. Water molecules tightly bound to proteins do not change protein modes so much but move together with proteins. Water molecules need to form hydrogen network to attain large fluctuation.
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