2011 Fiscal Year Final Research Report
Preparative synthesis of polysaccharide by using direct activation method
| Project/Area Number |
21750109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
NOGUCHI Masato 東北大学, 大学院・工学研究科, 助教 (10400285)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 酵素触媒重合反応 / 多糖合成 / 活性化糖誘導体 / 大量合成 |
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| Research Abstract |
To obtain the polysaccharide consisting of definite structure, a preparative synthetic method for monomer and enzymatic polymerization reaction were investigated. We have achieved direct synthesis of monomer substrate from free saccharide and successively obtained 1. 8g amounts of monomer. We have also developed a novel condensing agent for the direct synthesis of oxazoline derivative in sufficient yield. One-pot polycondensation reaction occurred by using of novel condensing agent and chitinase.
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[Journal Article] Crystal Structures of Glycoside Hydrolase Family 51.-L-Arabinofuranosidase from Thermotoga maritime.2012
Author(s)
Im, D. ; Kimura, K. ; Hayasaka, F. ; Tanaka, T. ; Noguchi, M. ; Kobayashi, A. ; Shoda, S. ; Miyazaki, K. ; Wakagi T. ; Fushinobu, S.
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Journal Title
Bioscience, Biotechnology, and Biochemistry 2012
Volume: 76
Pages: 423-428
Peer Reviewed
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[Journal Article] Direct dehydrative pyridylthio-glycosidation of unprotected sugars in aqueous media using 2-Chloro-1, 3-dimethylimidazolinium chloride as a condensing agent.2011
Author(s)
Yoshida, N. ; Noguchi, M. ; Tanaka, T. ; Matsumoto, T. ; Aida, N. ; Ishihara, M. ; Kobayashi, A. ; Shoda, S.
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Journal Title
Chemistry an Asian Journal 2011
Volume: 6,(7)
Pages: 1876-1885
Peer Reviewed
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[Journal Article] 4, 6-Dimethoxy-1, 3, 5-triazine oligoxyloglucans : Novel one-step preparable substrates for studying action of endo-beta-1, 4-glucanase III from Trichoderma reesei.2010
Author(s)
Kobayashi, A. ; Tanaka, T. ; Watanabe, K. ; Ishihara, M. ; Noguchi, M. ; Okada, H. ; Morikawa, Y. ; Shoda, S.
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Journal Title
Bioorganic & Medicinal Chemistry Letters 2010
Volume: 20 (12)
Pages: 3588-3591
Peer Reviewed
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[Journal Article] Efficient transfer of sialo-oligosaccharide onto proteins by combined use of a glycosynthase-like mutant of Mucor hiemalis endoglycosidase and synthetic sialo-complex-type sugar oxazoline.2010
Author(s)
Umekawa, M. ; Higashiyama, T. ; Koga, Y. ; Tanaka, T. ; Noguchi, M. ; Kobayashi, A. ; Shoda, S. ; Huang, W. ; Wang, L. X. ; Ashida, H. ; Yamamoto, K.
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Journal Title
Biochimica Et Biophysica Acta-General Subjects 2010
Volume: 1800 (11)
Pages: 1203-1209
Peer Reviewed
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