Creation of novel silyl photosensitizer absorbed on nanoparticle for photodynamic therapy

2010 Fiscal Year Final Research Report

• Project/Area Number: 21750133
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional materials chemistry
• Research Institution: Gunma University
• Principal Investigator: HORIUCHI Hiroaki Gunma University, 大学院・工学研究科, 助教 (00334136)
• Project Period (FY): 2009 – 2010
• Keywords: 光線力学療法 / 一重項酸素 / ケイ素 / 光増感剤 / ナノ粒子

Research Abstract

Developments of photosensitizer for photodynamic therapy were carried out. New silyl-photosensitizer shows higher sensitization efficiency of singlet oxygen and higher cellular uptake efficiency than previous one. The silylation also improved the selectively accumulating efficiency to tumor. Photodynamic activity for tumor-bearing mice was significantly enhanced by the silylation. Hybridization of a silyl-photosensitizer with silica nanoparticle was carried out to improve the selectively accumulating efficiency to tumor. It was confirmed that the hybrid material shows high sensitization efficiency of singlet oxygen in organic solvent.

Research Products

• [Journal Article] Suppression mechanism of the photodegradation of J-aggregate thin films of cyanine dyes by coating with polysilanes (2011)
  • Author(s): Horiuchi, H., Ishida, S., Matsuzaki, K., Tani, K., Hashimoto, T., Hotta, H., Tsunoda, K., Kodaira, T., Okutsu, T., Hiratsuka, H.
  • Journal Title: J.Phys.Chem.C 115(14) Pages: 6902-6909
  • Peer Reviewed
• [Journal Article] Singlet molecular oxygen generation by water-soluble phthalocyanine dendrimers with different aggregation behavior (2011)
  • Author(s): Nishida, M., Horiuchi, H., Momotake, A., Nishimura, Y., Hiratsuka, H., Arai, T.
  • Journal Title: J.Porphyr.Phthalocyanines 15(1) Pages: 47-53
  • Peer Reviewed
• [Journal Article] Silylation Enhancement of Photodynamic Activity of Tetraphenylporphyrin Derivative
  • Author(s): Horiuchi, H., Kameya, T., Hosaka, M.Yoshimura, K., Kyushin, S., Matsumoto, H., Okutsu, T., Takeuchi, T., Hiratsuka, H.
  • Journal Title: J.Photochem.Photobiol.A in press.
  • Peer Reviewed
• [Presentation] ケイ素ポルフィリンによる担癌マウスの光線力学治療 (2011)
  • Author(s): 堀内宏明・眞塩広之・石田真太郎・久新荘一郎・穂坂正博・竹内利行・奥津哲夫・平塚浩士
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学
  • Year and Date: 2011-03-27
• [Presentation] Development of Silicon-containing Photosensitizer for Photodynamic Thera py (2010)
  • Author(s): Horiuchi, H., Kameya, T., Yoshimuta, K.,Kyushin, S.,Matsumoto, H.,Hosaka, M., Takeuchi, T.,Okutsu, T.,Hiratsuka, H.
  • Organizer: PacifiChem 2010
  • Place of Presentation: Haw aii(USA)
  • Year and Date: 2010-12-19
• [Presentation] Development of Silic on-containing Photosensitizer for Photo dynamic Therapy -in vivo study- (2010)
  • Author(s): H.Horiuchi, H.Mashio, M.hosaka, S.Ishida, S.Kyushin, T.Okutsu, T.Takeuchi, H.Hiratsuka
  • Organizer: Interna tional Symposium on Silicon Science 2010
  • Place of Presentation: Gunma
  • Year and Date: 2010-12-09
• [Presentation] 含ケイ素光増感色素による担がんマウスの光線力学治療 (2010)
  • Author(s): 眞塩広之、堀内宏明、穂坂正博、竹内利行、石田真太郎、久新荘一郎、奥津哲夫、平塚浩士
  • Organizer: 第14回ケイ素化学協会シンポジウム
  • Place of Presentation: ニユーウェルシティ湯河原
  • Year and Date: 2010-11-19
• [Presentation] ケイ素含有光増感色素の開発:光物性とin vivo評価 (2010)
  • Author(s): 堀内宏明・眞塩広之・穂坂正博・竹内利行・石田真太郎・久新荘一郎・奥津哲夫・平塚浩士
  • Organizer: 2010年光化学討論会
  • Place of Presentation: 千葉大学
  • Year and Date: 2010-09-10
• [Presentation] ポルフィリン類縁体の一重項酸素光増感過程に及ぼす第14族元素の効果 (2010)
  • Author(s): 堀内宏明・眞塩広之・石田真太郎・久新荘一郎・松本英之・穂坂正博・竹内利之・平塚浩士
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 東大阪
  • Year and Date: 2010-03-26
• [Presentation] 光線力学療法に用いるケイ素型光増感色素の開発-シリルクロリンの光物性 (2009)
  • Author(s): 堀内宏明・亀谷剛大・斉藤裕太・吉村公男・久新荘一郎・松本英之・平塚浩士
  • Organizer: 日本化学会関東支部群馬地区地域懇談会
  • Place of Presentation: 前橋
  • Year and Date: 2009-12-05
• [Presentation] 光線力学療法への応用を目指したケイ素を含む光増感色素の開発 (2009)
  • Author(s): 堀内宏明・眞塩広之・斉藤裕太・石田真太郎・久新荘一郎・松本英之・穂坂正博・竹内利行・平塚浩士
  • Organizer: 第13回ケイ素化学協会シンポジウム
  • Place of Presentation: 唐津
  • Year and Date: 2009-10-30
• [Presentation] In vitroとin vivoでのカルボキシル基を有する光線力学療法用の含ケイ素光増感色素の研究 (2009)
  • Author(s): 眞塩広之、堀内宏明、亀谷剛大、石田真太郎、吉村公男、久新荘一郎・穂坂正博、竹内利行、松本英之、平塚浩士
  • Organizer: 第13回ケイ素化学協会シンポジウム
  • Place of Presentation: 唐津
  • Year and Date: 2009-10-30
• [Presentation] Development of Silicon-containing Photosensitizer for Photodynamic Therapy (2009)
  • Author(s): Hiroaki Horiuchi, Hiroyuki Mashio, Yuta Saito, Shintaro Ishida, Soichiro Kyushin, Hideyuki Matsumoto Masahiro Hosaka, Toshiyuki Takeuchi, Hiroshi Hiratsuka
  • Organizer: The 4th International Symposium for Young Elements Chemists 2009 Workshop on Organometallic Chemistry
  • Place of Presentation: Kasuga
  • Year and Date: 2009-10-28
• [Presentation] 光線力学療法への応用を目指したケイ素型光増感色素の開発 (2009)
  • Author(s): 堀内宏明・眞塩広之・亀谷剛大・吉村公男・斉藤裕太・石田真太郎・久新荘一郎・松本英之・穂坂正博・竹内利之・平塚浩士
  • Organizer: 第20回基礎有機化学討論会
  • Place of Presentation: 桐生
  • Year and Date: 2009-09-26
• [Presentation] 光線力学療法への応用を目指したケイ素型光増感色素の開発 (2009)
  • Author(s): 堀内宏明・亀谷剛大・眞塩広之・穂坂正博・竹内利之・斉藤裕太・久新荘一郎・平塚浩士
  • Organizer: 2009年光化学討論会
  • Place of Presentation: 桐生
  • Year and Date: 2009-09-18
• [Presentation] カルボキシル基を有する光線力学療法用癌ケイ素光増感色素の生体内での研究 (2009)
  • Author(s): 眞塩広之、堀内宏明、亀谷剛大、穂坂正博、竹内利行、石田真太郎、吉村公男、久新荘一郎、松本英之、平塚浩士
  • Organizer: 2009年光化学討論会
  • Place of Presentation: 桐生
  • Year and Date: 2009-09-18
• [Patent(Industrial Property Rights)] 含ケイ素置換基を導入した化合物、並びにそれを含む-重項酸素発生剤及び癌治療薬 (2010)
  • Inventor(s): 堀内宏明, 穂坂正博, 平塚浩士, 竹内利行, 久新荘一郎, 石田真太郎
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Industrial Property Number: 特願,2010-196568
  • Filing Date: 2010-09-02