2010 Fiscal Year Final Research Report
Development of siRNAs conjugated with bioactive molecule
| Project/Area Number |
21750180
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
TAKANORI Kubo Yasuda Women's University, 薬学部・薬学科, 助教 (90435751)
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| Project Period (FY) |
2009 – 2010
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| Keywords | バイオテクノロジー / 核酸 / 発現抑制 |
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| Research Abstract |
RNAi technology is a powerful tool for suppressing gene expression in mammalian cells. In this study, we developed siRNAs conjugated with bioactive molecules in order to enhance potency of RNAi. The siRNAs conjugated with bioactive molecules had potent RNAi efficacy, higher nuclease stability, and efficient membrane permeability. Moreover, excellent gene-silencing efficacies of siRNAs conjugated with bioactive molecules were found in a subcutaneously implanted tumor mouse model. Our developed siRNAs conjugated with bioactive molecules are among the promising candidates for a new generation of modified-siRNAs that can solve the many problems associated with RNAi.
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[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin's lymphoma.2010
Author(s)
Keichiro Mihara, Kazuyoshi Yanagihara, Misato Takigahira, Akira Kitanaka, Chihaya Imai, Joyeeta Bhattacharyya, Takanori Kubo, Yoshifumi Takei, Shin-ichiro Yasunaga, Yoshihiro Takihara, Akiro Kimura.
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Journal Title
Br J Haematol. 151
Pages: 37-46
Peer Reviewed
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