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2011 Fiscal Year Final Research Report

Preparation of Intelligent Gel by the Formation of Polyion Complex with Alternative Immersion Approach

Research Project

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Project/Area Number 21750220
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Polymer/Textile materials
Research InstitutionOsaka University

Principal Investigator

AJIRO Hiroharu  大阪大学, 臨床医工学融合研究教育センター, 特任准教授(常勤) (50437331)

Project Period (FY) 2009 – 2011
Keywordsゲル / 薬物伝達システム
Research Abstract

Taking advantage of different solubility of poly(vinylamine) and poly(N-vinylamide) s, surface-cationized gel was prepared by applying layer-by-layer approach. The second polymer network was introduced into the gel to obtain the" surface polyion complex gel(sPIC gel)", which only surface moiety is responsive to the circumstance change. sPIC gel suppressed neutral polymer at pH 7 and anionic low molecules, respectively.

  • Research Products

    (19 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) Presentation (10 results) Remarks (2 results)

  • [Journal Article] Thermosensitive Biodegradable Homopolymer of Trimethylene Carbonate Derivative at Body Temperature2012

    • Author(s)
      Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi
    • Journal Title

      Macromolecules

      Volume: 45(6) Pages: 2668-2674

  • [Journal Article] Radical Polymerization of Novel N-Substituted-N-vinylformamide Derivatives with Bulky Chiral Substituents2012

    • Author(s)
      Hiroharu Ajiro, Mitsuru Akashi
    • Journal Title

      J. Polym. Sci. Part A : Polym. Chem

      Volume: 50(1) Pages: 134-141

  • [Journal Article] Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Stimuli Responsive Polymers Applied to Novel Amphiphilic Gel2011

    • Author(s)
      Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
    • Journal Title

      J. Nanosci. Nanotech

      Volume: 11(8) Pages: 7047-7049

  • [Journal Article] Fabrication of Surface-Modified Hydrogels with Polyion Complex for Controlled Release2010

    • Author(s)
      Yukie Takemoto, Hiroharu Ajiro, Taka-aki Asoh, Mitsuru Akashi
    • Journal Title

      Chem. Mater

      Volume: 22(9) Pages: 2923-2929

  • [Journal Article] Nano Grape Formation by isotacitc-Poly(methacrylic acid)-block-poly(butyl acrylate)2010

    • Author(s)
      Hiroharu Ajiro, Mitsuru Akashi
    • Journal Title

      Macromol. Rapid Commun.

      Volume: 31(8) Pages: 714-717

  • [Journal Article] Cell Proliferation on Stereoregular isotactic-Poly(propylene oxide) as a Bulk Substrate2010

    • Author(s)
      Hiroharu Ajiro, Mitsuru Akashi
    • Journal Title

      Biomacromolecules

      Volume: 11(11) Pages: 2840-2844

  • [Journal Article] Novel Polyion Complex with Interpenetrating Polymer Network of Poly(acrylic acid) and Partially Protected Poly(vinylamine) Using N-Vinylacetamide and N-Vinylformamide2009

    • Author(s)
      Hiroharu Ajiro, Yukie Takemoto, Taka-aki Asoh, Mitsuru Akashi
    • Journal Title

      Polymer

      Volume: 50(15) Pages: 3503-3507

  • [Presentation] ポリ(N-ビニルアミド)ゲルの表面カチオン化とポリイオンコンプレックスを利用した薬物徐放制御2011

    • Author(s)
      網代広治・竹村一哉・明石満
    • Organizer
      第60回高分子学会討論会、1L11
    • Place of Presentation
      岡山(岡山大学津島キャンパス)
    • Year and Date
      20110928-30
  • [Presentation] 表面ポリイオンコンプレックスゲルによる二種類の薬物徐放制御(Dual drug release system by surface polyion complex hydrogel)2011

    • Author(s)
      網代広治・明石満
    • Organizer
      第60回高分子学会年次大会、3L16
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      20110525-27
  • [Presentation] 高分子構造制御による新規素材探索2011

    • Author(s)
      網代広治
    • Organizer
      第11回次世代医工学研究会、ショートプレゼン
    • Place of Presentation
      大阪(大阪大学吹田キャンパス)
    • Year and Date
      2011-10-21
  • [Presentation] 相互侵入網目構造を導入したポリ(N-ビニルアミド)ゲルの新規材料創製2011

    • Author(s)
      網代広治
    • Organizer
      高分子学会精密ネットワークポリマー研究会
    • Place of Presentation
      兵庫(兵庫県立大学姫路書写キャンパス書写記念会館)
    • Year and Date
      2011-03-08
  • [Presentation] 立体規則性合成高分子を用いた表面修飾における構造と生体適合性評価2010

    • Author(s)
      網代広治・明石満
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島(グランドプリンスホテル広島)
    • Year and Date
      20101129-30
  • [Presentation] Simple Polyion Complex Hydrogel by Poly(acrylic acid) and Partially Protected Poly(vinylamine)2009

    • Author(s)
      Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
    • Organizer
      11th Pacific Polymer Conference 2009, PPC 11, Cairns Convention Centre
    • Place of Presentation
      Cairns(Australia)
    • Year and Date
      20091206-10
  • [Presentation] 表面に刺激応答性ポリイオンコンプレックス膜を有するゲルの調製と薬物放出制御2009

    • Author(s)
      竹本友紀恵・網代広治・麻生隆彬・明石満
    • Organizer
      第58回高分子学会討論会、2L3-03
    • Place of Presentation
      熊本(熊本大学工学部)
    • Year and Date
      20090916-18
  • [Presentation] 薬物放出制御のためのポリ(N-ビニルアミド)ゲルの表面改質2009

    • Author(s)
      竹本友紀恵・網代広治・明石満
    • Organizer
      日本バイオマテリアル学会第4回関西若手研究発表会
    • Place of Presentation
      大阪(大阪大学銀杏会館)
    • Year and Date
      2009-08-07
  • [Presentation] Amphiphilic poly(N-vinylacetamide) hydrogel modified with interpenetrating network approach for transdermal therapeutic systems2009

    • Author(s)
      Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi
    • Organizer
      The 36th International Congress of Physiological Sciences
    • Place of Presentation
      京都(国際会館)
    • Year and Date
      2009-07-29
  • [Presentation] ポリイオンコンプレックスにより表面被覆されたゲルの調製と薬物放出制御2009

    • Author(s)
      竹本友紀恵・網代広治・麻生隆彬・明石満
    • Organizer
      第55回高分子研究会
    • Place of Presentation
      神戸(兵庫県民会館)
    • Year and Date
      2009-07-17
  • [Remarks] 研究室のホームページ

    • URL

      http://www.chem.eng.osaka-u.ac.jp/~akashi-lab/member/ajiro/ajiro_profile.html

  • [Remarks] 大学の個人研究者のページ

    • URL

      http://www.dma.jim.osaka-u.ac.jp/view?l=ja & u=7677 & f1=06 & sm=field & sl=ja & sp=1

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Published: 2013-07-31  

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